Interleukin-6, tumor necrosis factor and corticosterone induction by central lipopolysaccharide in aged rats

被引：33

作者：

Terrazzino, S ^{[1
]}

Perego, C ^{[1
]}

DeLuigi, A ^{[1
]}

DeSimoni, MG ^{[1
]}

机构：

[1] IST RIC FARMACOL MARIO NEGRI, I-20157 MILAN, ITALY

来源：

LIFE SCIENCES | 1997年 / 61卷 / 07期

关键词：

aging interleukin-6; tumor necrosis factor; corticosterone; Sprague-Dawley rats; lipopolysaccharide;

D O I：

10.1016/S0024-3205(97)00534-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Age-related changes of the immune-adrenal axis were studied in rats treated intracerebroventricularly with lipopolysaccharide ( LPS, 2.5 mu g/5 mu l). Serum interleukin-6 (IL-6), tumor necrosis factor (TNF) and corticosterone levels were evaluated in young (3 months) and old (24 months) Sprague-Dawley rats at different time-points. Old rats showed higher IL-6 levels compared to young rats while no change was observed on TNF levels in the two age groups. Corticosterone increase induced by LPS was lower in old than in young rats. The results show that heterogeneous modifications of the immune-adrenal axis occur that could have a pathophysiological role in the altered response to brain infections during aging.

引用

页码：695 / 701

页数：7

共 24 条

[1]

AGGARWAL BB, 1985, J BIOL CHEM, V260, P2345

[2]

BERTOLUCCI M, 1996, IN PRESS NEUROREPORT

[3] SUPPRESSION OF NATURAL-KILLER CELL-ACTIVITY IN YOUNG AND OLD MICE [J].