Role of microRNAs in haemopoiesis, heart hypertrophy and cancer

被引：8

作者：

Fontana, Laura ^{[1
]}

Sorrentino, Antonio ^{[1
]}

Condorelli, Gianluigi ^{[2
]}

Peschle, Cesare ^{[1
,2
]}

机构：

[1] Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy

[2] IRCCS MultiMed, I-20099 Milan, Italy

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

关键词：

cancer; haemopoiesis; heart hypertrophy; microRNA (miRNA);

D O I：

10.1042/BST0361206

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

miRNAs (microRNAs) are important regulatory molecules that control gene expression in all eukaryotes. miRNAs play an essential role in basic cellular activities such as proliferation, differentiation, morphogenesis and apoptosis. in haemopoiesis, several miRNA-based pathways have been identified. Importantly, miRNA mutations or mis-expression correlate with various human diseases. in cancer, deregulated miRNAs can function as tumour suppressors or oncogenes. The present review focuses on the recent literature concerning the role of miRNAs in three different research areas: haematology, cardiology and oncology, with particular focus on the results obtained by our group.

引用

页码：1206 / 1210

页数：5

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