Predictive, preventive, personalized and participatory medicine: back to the future

被引：110

作者：

Auffray, Charles ^{[1
]}

Charron, Dominique ^{[2
,3
]}

Hood, Leroy ^{[4
]}

机构：

[1] CNRS Inst Biol Sci, F-94801 Villejuif, France

[2] INSERM, U940, Jean Dausset Lab, F-75475 Paris 10, France

[3] Paris Diderot Univ, Hop St Louis, F-75475 Paris 10, France

[4] Inst Syst Biol, Seattle, WA 98103 USA

来源：

GENOME MEDICINE | 2010年 / 2卷

关键词：

SYSTEMS BIOLOGY; IMMUNOGENETICS; HLA;

D O I：

10.1186/gm178

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The pioneering work of Jean Dausset on the HLA system established several principles that were later reflected in the Human Genome Project and contributed to the foundations of predictive, preventive, personalized and participatory (P4) medicine. To effectively develop systems medicine, we should take advantage of the lessons of the HLA saga, emphasizing the importance of exploring a fascinating but mysterious biology, now using systems principles, pioneering new technology developments and creating shared biological and information resources.

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