MTHFR 677CT And 1298AC POLYMORPHISMS IN CHILDREN WITH DOWN SYNDROME AND ACUTE MYELOID LEUKEMIA IN BRAZIL

被引：7

作者：

Amorim, Marcia R. ^{[1
]}

Zanrosso, Crisiane Wais

Magalhaes, Isis Q. ^{[2
,3
]}

Pereira, Simone C. ^{[3
]}

Figueiredo, Alexandre

Emerenciano, Mariana

Pinheiro, Vitoria Regia ^{[4
]}

d'Andrea, Maria Lydia ^{[5
]}

Orioli, Ieda M. ^{[6
]}

Koifman, Sergio ^{[7
]}

Pombo-de-Oliveira, Maria. S.

机构：

[1] Inst Nacl Canc, Res Ctr Expt Med, Pediat Hematol Oncol Program, BR-20231050 Rio De Janeiro, Brazil

[2] Hosp Apoio Brasilia, Brasilia, DF, Brazil

[3] Inst Nacl Canc, Div Expt Med, Rio De Janeiro, Brazil

[4] Ctr Infantil Boldrini, Campinas, SP, Brazil

[5] Hosp Darcy Vargas, Dept Pediat Oncol, Sao Paulo, Brazil

[6] Univ Fed Do, Inst Biol, Dept Genet, Rio De Janeiro, Brazil

[7] Fiocruz MS, Escola Nacl Saude Publ, BR-21045900 Rio De Janeiro, Brazil

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2008年 / 25卷 / 08期

关键词：

677CT; 1298AC; acute leukemia; MTHFR; Down syndrome;

D O I：

10.1080/08880010802435104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Down syndrome (DS) is an important risk factor associated with acute leukemia (AL). The presence of polymorphisms that reduce 5,10-methylenetetrahydrofolate reductase (MTHFR) activity has been linked to the multifactorial leukemogenic process. The authors have conducted a study to test whether 677CT and/or 1298AC polymorphisms of MTHFR would play an additional role in susceptibility of acute myeloid leukemia (AML) in DS children. They also verified whether any polymorphism in the MTHFR gene was associated with the risk of DS. Genetic polymorphisms determination was carried out in 248 samples from healthy individuals as controls and a total of 115 DS children (65 without leukemia and 50 with AML). The present study failed to reveal any association between these polymorphisms and risk of AML in DS children. The data also indicate that MTHFR polymorphisms are not associated with risk of being a DS child.

引用

页码：744 / 750

页数：7

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