Prediction and design of macromolecular structures and interactions

被引：52

作者：

Baker, D ^{[1
]}

机构：

[1] Univ Washington, Seattle, WA 98112 USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2006年 / 361卷 / 1467期

关键词：

computational biophysics; protein structure prediction; protein design;

D O I：

10.1098/rstb.2005.1803

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this article, I summarize recent work from my group directed towards developing an improved model of intra and intermolecular interactions and applying this improved model to the prediction and design of macromolecular structures and interactions. Prediction and design applications can be of great biological interest in their own right, and also provide very stringent and objective tests which drive the improvement of the model and increases in fundamental understanding. I emphasize the results from the prediction and design tests that suggest progress is being made in high-resolution modelling, and that there is hope for reliably and accurately computing structural biology.

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收藏

页码：459 / 463

页数：5

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