New perspectives in melatonin uses

被引：145

作者：

Carpentieri, A. ^{[1
,2
]}

Diaz de Barboza, G. ^{[1
]}

Areco, V. ^{[1
]}

Peralta Lopez, M. ^{[1
]}

Tolosa de Talamoni, N. ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Catedra Bioquim & Biol Mol, Fac Ciencias Med, Lab Dr Fernando Canas, RA-5000 Cordoba, Argentina

[2] Univ Nacl Cordoba, Fac Odontol, Catedra Quim Biol, RA-5000 Cordoba, Argentina

来源：

PHARMACOLOGICAL RESEARCH | 2012年 / 65卷 / 04期

关键词：

Melatonin receptors; Melatonin metabolism; Antioxidant properties; Central nervous system; Cancer; Gastrointestinal tract; OXIDATIVE STRESS; BRIGHT-LIGHT; SLEEP DISTURBANCES; PARKINSONS-DISEASE; CIRCADIAN-RHYTHM; NITRIC-OXIDE; CANCER CELLS; DOUBLE-BLIND; RECEPTOR; PROTECTS;

D O I：

10.1016/j.phrs.2012.01.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review summarizes the metabolism, secretion, regulation and sites of action of melatonin. An updated description of the melatonin receptors, including their signal transduction mechanisms, distribution and characterization of receptor genes, is given. Special emphasis is focused on the clinical aspects and potential uses of melatonin in the sleep-wake rhythms, in the immune function, in cancer therapy, in neuroprotection against oxidative damage and antioxidant activities in different tissues. Finally, combined effects of melatonin with other drugs are discussed. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：437 / 444

页数：8

共 91 条

[1] The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia [J].