Changes in plasma cytokines induced by interferon-β1a treatment in patients with multiple sclerosis

被引：26

作者：

Duddy, ME

Armstrong, MA

Crockard, AD

Hawkins, SA

机构：

[1] Queens Univ Belfast, Royal Victoria Hosp, Dept Med, Belfast BT12 6BN, Antrim, North Ireland

[2] Queens Univ Belfast, Royal Victoria Hosp, Dept Microbiol & Immunobiol, Belfast BT12 6BN, Antrim, North Ireland

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1999年 / 101卷 / 01期

关键词：

multiple sclerosis; interferon-beta; cytokines;

D O I：

10.1016/S0165-5728(99)00103-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It has been postulated that the efficacy of interferon-beta 1a in multiple sclerosis may be due to the induction of type 2 cytokines. in this report we demonstrate that after 3 months of therapy, there is no sustained alteration in the plasma levels of type 1 (IL-12, IL-1 beta and TNF-alpha) or type 2 (IL-6, IL-10) cytokines, but rather repeated induction of both with each injection. Little alteration is seen in the profile of cytokines induced with time, despite a decline in side effects. This suggests that IFN-Pla causes repented transient modulation of cytokine expression, but no sustained deviation in the type 1/type 2 balance. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：98 / 109

页数：12

共 25 条

[1] Comparative pharmacokinetics and pharmacodynamics of two recombinant human interferon beta-1a (IFN beta-1a) products administered intramuscularly in healthy male and female volunteers [J].