A Novel Role for the Hypoxia Inducible Transcription Factor HIF-1α Critical Regulation of Inflammatory Cell Function

被引：80

作者：

Cramer, Thorsten ^{[1
]}

Johnson, Randall S. ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Biol Sci, Mol Biol Sect, La Jolla, CA 92093 USA

来源：

CELL CYCLE | 2003年 / 2卷 / 03期

关键词：

Innate immunity; Inflammation; Glycolysis; Hypoxia; HIF-1; alpha;

D O I：

10.4161/cc.2.3.402

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

[No abstract available]

引用

页码：192 / 193

页数：2

共 14 条

[1] HIF-1α is essential for myeloid cell-mediated inflammation [J].

Cramer, T ;

Yamanishi, Y ;

Clausen, BE ;

Förster, I ;

Pawlinski, R ;

Mackman, N ;

Haase, VH ;

Jaenisch, R ;

Corr, M ;

Nizet, V ;

Firestein, GS ;

Gerber, HP ;

Ferrara, N ;

Johnson, RS .

CELL, 2003, 112 (05) :645-657

[2] Hypoxia regulates β-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element [J].

Discher, DJ ;

Bishopric, NH ;

Wu, XS ;

Peterson, CA ;

Webster, KA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) :26087-26093

[3] Innate immune recognition [J].

Janeway, CA ;

Medzhitov, R .

ANNUAL REVIEW OF IMMUNOLOGY, 2002, 20 :197-216

[4] The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer [J].

Kim, W ;

Kaelin, WG .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2003, 13 (01) :55-60

[5]

Levene PA, 1912, J BIOL CHEM, V11, P361

[6] Advances in immunology: Innate immunity. [J].

Medzhitov, R ;

Janeway, CJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (05) :338-344

[7] The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis [J].

Pugh, CW ;

Ratcliffe, PJ .

SEMINARS IN CANCER BIOLOGY, 2003, 13 (01) :83-89

[8] HIF-1α is required for solid tumor formation and embryonic vascularization [J].

Ryan, HE ;

Lo, J ;

Johnson, RS .

EMBO JOURNAL, 1998, 17 (11) :3005-3015

[9] Regional manifestations and control of the immune system [J].

Saadi, S ;

Wrenshall, LE ;

Platt, JL .

FASEB JOURNAL, 2002, 16 (08) :849-856

[10]

Schor H, 2000, Dev Immunol, V7, P227, DOI 10.1155/2000/51902

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