Gin → Arg 191 polymorphism of paraoxonase and Parkinson's disease

被引:26
作者
Akhmedova, S
Anisimov, S
Yakimovsky, A
Schwartz, E
机构
[1] Russian Acad Sci, St Petersburg Inst Nucl Phys, Lab Human Mol Genet, Gatchina 188350, Russia
[2] St Petersburg State Univ, Dept Normal Physiol, St Petersburg, Russia
关键词
Parkinson's disease; paraxonase; organophosphates;
D O I
10.1159/000022868
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We investigated the Gln --> Arg 191 polymorphism-in paraoxonase (PON1) in St. Petersburg population, in three clinically differentiated groups of patients with Parkinson's disease (PD) and in the symptomatic tremor group. A new approach for Gln --> Arg 191 PON1 polymorphism genotyping is suggested. No significant differences in the groups studies as compared to the controls was observed.
引用
收藏
页码:178 / 180
页数:3
相关论文
共 13 条
[1]  
ADKINS S, 1993, AM J HUM GENET, V52, P598
[2]   How far are we in understanding the cause of Parkinson's disease? [J].
BenShlomo, Y .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1996, 61 (01) :4-16
[3]   SERUM PARAOXONASE AND ITS INFLUENCE ON PARAOXON AND CHLORPYRIFOS-OXON TOXICITY IN RATS [J].
COSTA, LG ;
MCDONALD, BE ;
MURPHY, SD ;
OMENN, GS ;
RICHTER, RJ ;
MOTULSKY, AG ;
FURLONG, CE .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1990, 103 (01) :66-76
[4]   RISK-FACTORS IN YOUNG-ONSET PARKINSONS-DISEASE [J].
GOLBE, LI .
NEUROLOGY, 1993, 43 (09) :1641-1643
[5]   PARKINSONISM - ONSET PROGRESSION AND MORTALITY [J].
HOEHN, MM ;
YAHR, MD .
NEUROLOGY, 1967, 17 (05) :427-&
[6]   RISK-FACTORS FOR PARKINSONS-DISEASE [J].
HUBBLE, JP ;
CAO, T ;
HASSANEIN, RES ;
NEUBERGER, JS ;
KOLLER, WC .
NEUROLOGY, 1993, 43 (09) :1693-1697
[7]   THE MOLECULAR-BASIS OF THE HUMAN SERUM PARAOXONASE ACTIVITY POLYMORPHISM [J].
HUMBERT, R ;
ADLER, DA ;
DISTECHE, CM ;
HASSETT, C ;
OMIECINSKI, CJ ;
FURLONG, CE .
NATURE GENETICS, 1993, 3 (01) :73-76
[8]   OXIDATIVE DAMAGE IN NEURODEGENERATIVE DISEASE [J].
JENNER, P .
LANCET, 1994, 344 (8925) :796-798
[9]   Environmental risk factors and Parkinson's disease: A case-control study in Taiwan [J].
Liou, HH ;
Tsai, MC ;
Chen, CJ ;
Jeng, JS ;
Chang, YC ;
Chen, SY ;
Chen, RC .
NEUROLOGY, 1997, 48 (06) :1583-1588
[10]   Dietary lipids and antioxidants in Parkinson's disease: A population-based, case-control study [J].
Logroscino, G ;
Marder, K ;
Cote, L ;
Tang, MX ;
Shea, S ;
Mayeux, R .
ANNALS OF NEUROLOGY, 1996, 39 (01) :89-94