Interleukin-6 is required for parasite specific response and host resistance to Trypanosoma cruzi

被引:68
作者
Gao, WD [1 ]
Pereira, MA [1 ]
机构
[1] Tufts Univ, Sch Med, Dept Pathol, Parasitol Res Ctr, Boston, MA 02111 USA
关键词
Chagas' disease; trypanosome; knockout; IL-6; immunity;
D O I
10.1016/S0020-7519(01)00322-8
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Infection with Trypanosoma cruzi, the agent of Chagas' disease, results in elevated levels of interleukin-6 (IL-6) in serum and infected tissues. However, it remains unknown whether IL-6 plays a role in host defence against T cruzi. To determine whether IL-6 underlies disease progression, we followed the time course of T cruzi-infected mice bearing IL-6 +/+ and -/- genotypes, respectively. We found that IL-6 -/- mice were more susceptible to T. cruzi infection as they exhibited about 3-fold higher parasitaemia and died earlier than wild-type animals. Unlike what might be expected, T cruzi-infected IL-6 -/- mice did not show at peak infection a decrease in the secretion of IFN-gamma, a Th 1 cytokine crucial for controlling the parasite. Instead, they exhibited a much reduced splenocyte recall response to T cruzi antigens. Our results suggest that IL-6 mediates anti-parasite protective responses against T cruzi. (C) 2002 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:167 / 170
页数:4
相关论文
共 24 条
[1]   Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis [J].
Boe, A ;
Baiocchi, M ;
Carbonatto, M ;
Papoian, R ;
Serlupi-Crescenzi, O .
CYTOKINE, 1999, 11 (12) :1057-1064
[2]   Induction of proinflammatory cytokine expression in experimental acute chagasic cardiomyopathy [J].
Chandrasekar, B ;
Melby, PC ;
Troyer, DA ;
Freeman, GL .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 223 (02) :365-371
[3]   TRYPANOSOMA-CRUZI TRANS-SIALIDASE - ENHANCEMENT OF VIRULENCE IN A MURINE MODEL OF CHAGAS-DISEASE [J].
CHUENKOVA, M ;
PEREIRA, MEA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (05) :1693-1703
[4]   Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection [J].
Dalrymple, SA ;
Slattery, R ;
Aud, DM ;
Krishna, M ;
Lucian, LA ;
Murray, R .
INFECTION AND IMMUNITY, 1996, 64 (08) :3231-3235
[5]   Cell-mediated immunity in experimental Trypanosoma cruzi infection [J].
DosReis, GA .
PARASITOLOGY TODAY, 1997, 13 (09) :335-342
[6]  
Eugster HP, 1998, EUR J IMMUNOL, V28, P2178, DOI 10.1002/(SICI)1521-4141(199807)28:07<2178::AID-IMMU2178>3.0.CO
[7]  
2-D
[8]   Involvement of CD4+ Th1 cells in systemic immunity protective against primary and secondary challenges with Trypanosoma cruzi [J].
Hoft, DF ;
Schnapp, AR ;
Eickhoff, CS ;
Roodman, ST .
INFECTION AND IMMUNITY, 2000, 68 (01) :197-204
[9]   IMPAIRED IMMUNE AND ACUTE-PHASE RESPONSES IN INTERLEUKIN-6-DEFICIENT MICE [J].
KOPF, M ;
BAUMANN, H ;
FREER, G ;
FREUDENBERG, M ;
LAMERS, M ;
KISHIMOTO, T ;
ZINKERNAGEL, R ;
BLUETHMANN, H ;
KOHLER, G .
NATURE, 1994, 368 (6469) :339-342
[10]   The roles of adhesion molecules and proteinases in lymphocyte transendothelial migration [J].
Madri, JA ;
Graesser, D ;
Haas, T .
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1996, 74 (06) :749-757