Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus

被引：84

作者：

Li, Ning ^{[1
]}

Zhang, Jia-Yu ^{[1
]}

Zeng, Ke-Wu ^{[1
]}

Zhang, Liang ^{[1
]}

Che, Yan-Yun ^{[1
]}

Tu, Peng-Fei ^{[1
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

FITOTERAPIA | 2012年 / 83卷 / 06期

关键词：

Ophiopogon japonicus; Homoisoflavonoids; Anti-inflammatory; Inhibitory effects of nitric oxide production; Ophiopogonone E; Ophiopogonanone H; NITRIC-OXIDE; SUBTERRANEAN PART; FIBROUS ROOTS; KER-GAWLER; CONSTITUENTS; CONGENERS; INJURY;

D O I：

10.1016/j.fitote.2012.05.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new homoisoflavonoids, named ophiopogonone E (1) and ophiopogonanone H (2), together with thirteen known ones (3-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analyses. Compounds 7 and 15 were isolated from the genus for the first time. In addition, compounds 2-15 were evaluated for their effects on the inhibition of NO production induced by lipopolysaccharide in the murine microglial cell line BV-2. Compounds 2, 4, 6, 7, 10, 11 showed potent inhibitory effects on NO production with IC50 values of 20.1, 17.0, 7.8, 5.1, 19.2 and 14.4 mu M respectively. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1042 / 1045

页数：4

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