MicroRNA profiling during rat ventricular maturation: A role for miR-29a in regulating cardiomyocyte cell cycle re-entry

被引：53

作者：

Cao, Xiaoqing ^{[1
,2
,3
,4
]}

Wang, Jue ^{[1
,2
,3
,4
,5
]}

Wang, Zhenhua ^{[1
,2
,3
,4
]}

Du, Juan ^{[1
,2
,3
,4
]}

Yuan, Xin ^{[1
,2
,3
,4
]}

Huang, Weicong ^{[5
]}

Meng, Jian ^{[1
,2
,3
,4
]}

Gu, Haiyong ^{[1
,2
,3
,4
]}

Nie, Yu ^{[1
,2
,3
,4
]}

Ji, Bingyang ^{[1
,2
,3
,4
]}

Hu, Shengshou ^{[1
,2
,3
,4
]}

Zheng, Zhe ^{[1
,2
,3
,4
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis,Fuwai Hosp, Beijing 100037, Peoples R China

[2] Chinese Acad Med Sci, Peking Union Med Coll, Fuwai Hosp, Dept Surg, Beijing 100037, Peoples R China

[3] Chinese Acad Med Sci, Peking Union Med Coll, Cardiovasc Inst, Beijing 100037, Peoples R China

[4] Natl Ctr Cardiovasc Dis, Minist Hlth, Key Lab Cardiac Regenerat Med, Beijing 100037, Peoples R China

[5] Wenzhou Med Coll, Affiliated Hosp 1, Dept Thorac & Cardiovasc Surg, Wenzhou 325000, Zhejiang, Peoples R China

来源：

FEBS LETTERS | 2013年 / 587卷 / 10期

关键词：

MicroRNA; Cardiomyocyte; Proliferation; Microarray; MicroRNA-29a; PROLIFERATION; HEART; EXPRESSION; HYPERTROPHY; GROWTH;

D O I：

10.1016/j.febslet.2013.01.075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies demonstrated that the mammalian heart possesses some capacity to proliferate. We observed cardiomyocyte proliferation within 4 weeks of age (P4W) in rats. We found 95 microRNAs that are differentially expressed in P4W cardiomyocytes. MicroRNA-29a was among the most highly up-regulated microRNAs in P4W cardiomyocytes. Overexpression of microRNA-29a suppressed the proliferation of H9c2 cell line. MicroRNA-29a inhibition induced cardiomyocytes to proliferate, accelerated the G1/S and G2/M transition, and up-regulated the cell cycle gene expression. Cyclin D2 (CCND2) was identified as a direct target of microRNA-29a. These findings indicate that microRNA-29a is involved in cardiomyocyte proliferation during postnatal development. Crown Copyright (C) 2013 Published by Elsevier B. V. on behalf of Federation of European Biochemical society. All rights reserved.

引用

页码：1548 / 1555

页数：8

共 25 条

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