V-SRC'S hold over actin and cell adhesions

被引:262
作者
Frame, MC
Fincham, VJ
Carragher, NO
Wyke, JA
机构
[1] Univ Glasgow, Beatson Inst Canc Res, Canc Res UK Beatson Labs, Glasgow G61 1BD, Lanark, Scotland
[2] Univ Glasgow, Inst Biomed & Life Sci, Canc Res UK Beatson Labs, Glasgow G61 1BD, Lanark, Scotland
关键词
D O I
10.1038/nrm779
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell-matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.
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页码:233 / 245
页数:13
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