Searching for regulatory elements in human noncoding sequences

被引：179

作者：

Duret, L ^{[1
]}

Bucher, P ^{[1
]}

机构：

[1] INST SUISSE RECH EXPT CANC, CH-1066 EPALINGES, SWITZERLAND

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(97)80058-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Important progress has been made in the past two years in the identification of Pol II promoters, For most other regulatory elements, however, current biological knowledge is still insufficient to allow the development of prediction tools. The phylogenetic-footprinting strategy, which is based on the comparative analysis of homologous sequences, is a very efficient approach to identify new unknown regulatory elements. The recent organization of large-scale sequencing projects for some model vertebrate organisms will be extremely valuable for the prediction of regulatory elements in the human genome. (C) Current Biology Ltd.

引用

页码：399 / 406

页数：8

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