Vaccination against Schistosoma mansoni infection using 74 kDa Schistosoma protein antigen

被引：6

作者：

Attallah, AM ^{[1
]}

Attia, H

Ismail, H

Yones, E

El-Nashar, EM

El-Kader, KA

Tabll, A

Saad, A

Sultan, A

机构：

[1] Biotechnol Res Ctr, New Damietta City, Egypt

[2] Univ Mansoura, Gastroenterol Ctr, Mansoura, Egypt

[3] Banha Fac Med, Benha, Egypt

[4] Cairo Univ, Fac Sci, Cairo, Egypt

来源：

VACCINE | 1999年 / 17卷 / 22期

关键词：

schistosoma; vaccination; protective 74 kDa antigen; resistance; granuloma; collagen;

D O I：

10.1016/S0264-410X(99)00090-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An IgG(2a) anti-Schistosoma mansoni mouse monoclonal antibody was shown to passively protect SH iss mice. The 74 kDa target antigen was isolated from antigenic extracts of S. mansoni adult worms. Swiss and C57 BL/6J mice were immunized with 30, 50, 100 and 200 mu g antigen/mouse doses with and without Freund's adjuvant. Sera of immunized mice showed high reactivity against 74 kDa antigen. The highest protection level (76.6% in Swiss mice and 50.1% in C57 BL/6J mice) was obtained using the 50 mu g antigen dose with and without Freund's adjuvant. A marked reduction in granuloma number and intensity of collagen and reticular granuloma fibers was observed. The 74 kDa antigen has the ability to protect mice of different strains and to modulate the host immune system. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2786 / 2791

页数：6

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