Initial clinical experience with IV tissue plasminogen activator for acute ischemic stroke: A multicenter survey

被引：140

作者：

Tanne, D

Bates, VE

Verro, P

Kasner, SE

Binder, JR

Patel, SC

Mansbach, HH

Daley, S

Schultz, LR

Karanjia, PN

Scott, P

Dayno, JM

Vereczkey-Porter, K

Benesch, C

Book, D

Coplin, WM

Dulli, D

Levine, SR

机构：

[1] Henry Ford Hosp, Detroit, MI 48202 USA

[2] Hlth Sci Ctr, Detroit, MI USA

[3] Dent Neurol Inst, Buffalo, NY USA

[4] New Jersey Neurosci Inst, Edison, NJ USA

[5] Univ Penn, Med Ctr, Philadelphia, PA 19104 USA

[6] Med Coll Wisconsin, Milwaukee, WI 53226 USA

[7] Marshfield Clin Fdn Med Res & Educ, Marshfield, WI 54449 USA

[8] Univ Michigan, Med Ctr, Ann Arbor, MI USA

[9] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA

[10] Univ Rochester, Strong Mem Hosp, Rochester, NY 14642 USA

[11] Univ Detroit, Ctr Hlth, Detroit, MI 48221 USA

[12] Univ Wisconsin, Madison, WI USA

来源：

NEUROLOGY | 1999年 / 53卷 / 02期

关键词：

D O I：

10.1212/WNL.53.2.424

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We assessed initial clinical experience with IV tissue plasminogen activator (t-PA) treatment of acute ischemic stroke in a standardized retrospective survey of hospitals with experienced acute stroke treatment sq stems. The incidence of symptomatic intracerebral hemorrhage (ICH) was 6% (11 of 189 patients; 95% CI 3 to 11%), similar to that in the National Institute of Neurological Disorders and Stroke (NINDS) t-PA Stroke Study. Deviations from the NINDS protocol guidelines were identified in 30% of patients (56 of 189). The incidence of symptomatic ICH was 11% among patients with protocol deviations as compared with 4% in patients who were treated according to the NINDS protocol guidelines, suggesting that strict adherence to protocol guidelines is prudent.

引用

页码：424 / 427

页数：4

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