Role of Matrix Metalloproteinases in Animal Models of Ischemic Stroke

被引：45

作者：

Lenglet, Sebastien ^{[1
]}

Montecucco, Fabrizio ^{[1
,2
]}

Mach, Francois ^{[1
]}

机构：

[1] Univ Hosp Geneva, Fdn Med Res, Dept Med, Div Cardiol, Geneva, Switzerland

[2] Univ Genoa, Dept Internal Med, Clin Internal Med 1, I-16126 Genoa, Italy

来源：

CURRENT VASCULAR PHARMACOLOGY | 2015年 / 13卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

Matrix metalloproteinase; inflammation; stroke; BLOOD-BRAIN-BARRIER; FOCAL CEREBRAL-ISCHEMIA; RAT-BRAIN; ENHANCES NEUROGENESIS; MEDIATED DISRUPTION; ADULT BRAIN; MATRIX-METALLOPROTEINASE-9; ACTIVATION; MMP-9; EXPRESSION;

D O I：

10.2174/15701611113116660161

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Matrix metalloproteinases (MMP) comprise a family of at least 25 zinc-dependent endopeptidases that play a pivotal role in the physiopathology of the mammalian central nervous system. In the first phases after stroke, the dysregulation of MMPs has been described to increase acute neurovascular disruption and cerebral injury. In particular, MMP-mediated alterations lead to blood-brain barrier (BBB) leakage, cerebral edema, hemorrhage, leukocyte infiltration and progressive inflammatory reactions underlying brain tissue loss. In addition, MMPs have been also shown to play critical activities during the repair phases of cerebral ischemia, particularly during angiogenesis and reestablishment of cerebral blood flow. The aim of this narrative review is to elucidate the mechanisms by which MMPs may provide detrimental and/or beneficial effects during the post-stroke injury and repair phases in animal models.

引用

页码：161 / 166

页数：6

共 83 条

[1] Subarachnoid haemorrhage [J].

Al-Shahi, Rustam ;

White, Philip M. ;

Davenport, Richard J. ;

Lindsay, Kenneth W. .

BMJ-BRITISH MEDICAL JOURNAL, 2006, 333 (7561) :235-240A

[2] Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke [J].

Anthony, DC ;

Ferguson, B ;

Matyzak, MK ;

Miller, KM ;

Esiri, MM ;

Perry, VH .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1997, 23 (05) :406-415

[3] Neuronal replacement from endogenous precursors in the adult brain after stroke [J].

Arvidsson, A ;

Collin, T ;

Kirik, D ;

Kokaia, Z ;

Lindvall, O .

NATURE MEDICINE, 2002, 8 (09) :963-970

[4] Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia [J].

Asahi, M ;

Wang, XY ;

Mori, T ;

Sumii, T ;

Jung, JC ;

Moskowitz, MA ;

Fini, ME ;

Lo, EH .

JOURNAL OF NEUROSCIENCE, 2001, 21 (19) :7724-7732

[5] Potential Animal Models of Lacunar Stroke A Systematic Review [J].

Bailey, Emma L. ;

McCulloch, James ;

Sudlow, Cathie ;

Wardlaw, Joanna M. .

STROKE, 2009, 40 (06) :E451-E458

[6] Endogenous Matrix Metalloproteinase (MMP)-3 and MMP-9 Promote the Differentiation and Migration of Adult Neural Progenitor Cells in Response to Chemokines [J].

Barkho, Basam Z. ;

Munoz, Ari E. ;

Li, Xuekun ;

Li, Lu ;

Cunningham, Lee Anna ;

Zhao, Xinyu .

STEM CELLS, 2008, 26 (12) :3139-3149

[7]

Benuck M, 1996, J NEUROCHEM, V67, P2019

[8] Elevation of cytoskeletal protein breakdown in aged Wistar rat brain [J].

Bernath, E ;

Kupina, N ;

Liu, MC ;

Hayes, RL ;

Meegan, C ;

Wang, KKW .

NEUROBIOLOGY OF AGING, 2006, 27 (04) :624-632

[9] Age effect on motor recovery in a post-acute animal stroke model [J].

Brown, AW ;

Marlowe, KJ ;

Bjelke, B .

NEUROBIOLOGY OF AGING, 2003, 24 (04) :607-614

[10] Mapping sites responsible for interactions of agrin with neurons [J].

Burgess, RW ;

Dickman, DK ;

Nunez, L ;

Glass, DJ ;

Sanes, JR .

JOURNAL OF NEUROCHEMISTRY, 2002, 83 (02) :271-284

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