RNA silencing: a conserved antiviral immunity of plants and animals

被引：161

作者：

Ding, SW ^{[1
]}

Li, HW

Lu, R

Li, F

Li, WX

机构：

[1] Ctr Plant Cell Biol, Dept Plant Pathol, Riverside, CA 92521 USA

[2] Univ Calif Riverside, Microbiol Program, Riverside, CA 92521 USA

来源：

VIRUS RESEARCH | 2004年 / 102卷 / 01期

基金：

美国国家卫生研究院;

关键词：

RNA silencin; RNAi; antiviral immunity; Drosophila;

D O I：

10.1016/j.virusres.2004.01.021

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

RNA silencing is a novel RNA-guided gene regulatory mechanism operational in a wide range of eukaryotic organisms from fission yeast, plants. to mammals. This article reviews the recent progress on aspects of RNA silencing that are related to its biological function as a conserved antiviral immunity of plants and animals, and highlights features of this novel antiviral response in invertebrate animals as compared to the known innate and adaptive immunities. Finally, we discuss evidence that suggests a natural antiviral role for RNA silencing in vertebrates as well as experimental approaches that may facilitate the identification of first mammalian Viral suppressors of RNA silencing. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：109 / 115

页数：7

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