IL-1 family in breast cancer: Potential interplay with leptin and other adipocytokines

被引：73

作者：

Perrier, Stephane ^{[1
]}

Caldefie-Chezet, Florence ^{[2
]}

Vasson, Marie-Paule ^{[2
,3
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Surg & Mol Oncol, Dundee DD1 9SY, Scotland

[2] Univ Clermont 1, UFR Pharm, EA4233, CRNH Auvergne, Clara, France

[3] Ctr Jean Perrin, Unite Nutr, F-63001 Clermont Ferrand 1, France

来源：

FEBS LETTERS | 2009年 / 583卷 / 02期

关键词：

IL-1; Leptin; Adipocytokine; Breast cancer; Obesity; INTERLEUKIN-1 RECEPTOR ANTAGONIST; ADIPOSE-TISSUE; CELL-PROLIFERATION; ESTROGEN-RECEPTOR; SJOGRENS-SYNDROME; GROWTH-FACTOR; UP-REGULATION; EXPRESSION; ADIPONECTIN; CYTOKINES;

D O I：

10.1016/j.febslet.2008.12.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity is associated with an increased risk of breast cancer. interleukin-1 (IL-1), a pro-inflammatory cytokine secreted by adipose tissue, is involved in breast cancer development. There is also convincing evidence that other adipocytokines including leptin not only have a role in haematopoiesis, reproduction and immunity but are also growth factors in cancer. Therefore, IL-1 family and leptin family are adipocytokines which could represent a major link between obesity and breast cancer progression. This minireview provides insight into recent findings on the prognostic significance of IL-1 and leptin in mammary tumours, and discusses the potential interplay between IL-1 family members and adipocyte-derived hormones in breast cancer. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：259 / 265

页数：7

共 93 条

[1] Effects of micro-environment- and malignant cell-derived interleukin-1 in carcinogenesis, tumour invasiveness and tumour-host interactions [J].

Apte, RN ;

Krelin, Y ;

Song, XP ;

Dotan, S ;

Recih, E ;

Elkabets, M ;

Carmi, Y ;

Dvorkin, T ;

White, RM ;

Gayvoronsky, L ;

Segal, S ;

Voronou, E .

EUROPEAN JOURNAL OF CANCER, 2006, 42 (06) :751-759

[2] Interleukin-1 receptor antagonist: Role in biology [J].

Arend, WP ;

Malyak, M ;

Guthridge, CJ ;

Gabay, C .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :27-55

[3] The balance between IL-1 and IL-1Ra in disease [J].

Arend, WR .

CYTOKINE & GROWTH FACTOR REVIEWS, 2002, 13 (4-5) :323-340

[4]

Bamberger AM, 1999, INT J CANCER, V84, P533, DOI 10.1002/(SICI)1097-0215(19991022)84:5<533::AID-IJC16>3.0.CO

[5]

2-J

[6] A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development [J].

Bar, D ;

Apte, RN ;

Voronov, E ;

Dinarello, CA ;

Cohen, S .

FASEB JOURNAL, 2004, 18 (01) :161-163

[7] Fatigue and proinflammatory cytokine activity in breast cancer survivors [J].

Bower, JE ;

Ganz, PA ;

Aziz, N ;

Fahey, JL .

PSYCHOSOMATIC MEDICINE, 2002, 64 (04) :604-611

[8] Leptin:: A proliferative factor for breast cancer?: Study on human ductal carcinoma [J].

Caldefie-Chézet, F ;

Damez, M ;

de Latour, M ;

Konska, G ;

Mishellani, F ;

Fusillier, C ;

Guerry, M ;

Penault-Llorca, F ;

Guillot, J ;

Vasson, MP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 334 (03) :737-741

[9] Leptin regulates functional capacities of polymorphonuclear neutrophils [J].

Caldefie-Chezet, F ;

Poulin, A ;

Vasson, MP .

FREE RADICAL RESEARCH, 2003, 37 (08) :809-814

[10]

Caldefie-Chezet F, 2001, J LEUKOCYTE BIOL, V69, P414

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