Controlling IGF-receptor function: A possible strategy for tumor therapy

被引：47

作者：

Baserga, R

机构：

[1] Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA

来源：

TRENDS IN BIOTECHNOLOGY | 1996年 / 14卷 / 05期

关键词：

D O I：

10.1016/0167-7799(96)10023-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The insulin-like growth factor-1 receptor (IGF-IR) is one of several growth-factor receptors that regulate the proliferation of mammalian cells. However, its ubiquitousness and certain unique aspects of its function make IGF-IR an ideal target for therapeutic interventions against abnormal growth, with very little effect on normal cells.

引用

页码：150 / 152

页数：3

共 18 条

[1]

BAKER J, 1993, CELL, V75, P73, DOI 10.1016/0092-8674(93)90680-O

[2]

BASERGA R, 1995, CANCER RES, V55, P249

[3] ONCOGENES AND THE STRATEGY OF GROWTH-FACTORS [J].