For better or worse? Telomerase inhibition and cancer

被引:104
作者
de Lange, T
Jacks, T
机构
[1] Rockefeller Univ, New York, NY 10021 USA
[2] MIT, Howard Hughes Med Inst, Dept Biol, Cambridge, MA 02139 USA
关键词
D O I
10.1016/S0092-8674(00)81955-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:273 / 275
页数:3
相关论文
共 21 条
[1]   FUNCTIONAL-CHARACTERIZATION AND DEVELOPMENTAL REGULATION OF MOUSE TELOMERASE RNA [J].
BLASCO, MA ;
FUNK, W ;
VILLEPONTEAU, B ;
GREIDER, CW .
SCIENCE, 1995, 269 (5228) :1267-1270
[2]   Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [J].
Blasco, MA ;
Lee, HW ;
Hande, MP ;
Samper, E ;
Lansdorp, PM ;
DePinho, RA ;
Greider, CW .
CELL, 1997, 91 (01) :25-34
[3]   The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit [J].
Bryan, TM ;
Marusic, L ;
Bacchetti, S ;
Namba, M ;
Reddel, RR .
HUMAN MOLECULAR GENETICS, 1997, 6 (06) :921-926
[4]   p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis [J].
Chin, L ;
Artandi, SE ;
Shen, Q ;
Tam, A ;
Lee, SL ;
Gottlieb, GJ ;
Greider, CW ;
DePinho, RA .
CELL, 1999, 97 (04) :527-538
[5]   TELOMERE SHORTENING ASSOCIATED WITH CHROMOSOME INSTABILITY IS ARRESTED IN IMMORTAL CELLS WHICH EXPRESS TELOMERASE ACTIVITY [J].
COUNTER, CM ;
AVILION, AA ;
LEFEUVRE, CE ;
STEWART, NG ;
GREIDER, CW ;
HARLEY, CB ;
BACCHETTI, S .
EMBO JOURNAL, 1992, 11 (05) :1921-1929
[6]   THE RNA COMPONENT OF HUMAN TELOMERASE [J].
FENG, JL ;
FUNK, WD ;
WANG, SS ;
WEINRICH, SL ;
AVILION, AA ;
CHIU, CP ;
ADAMS, RR ;
CHANG, E ;
ALLSOPP, RC ;
YU, JH ;
LE, SY ;
WEST, MD ;
HARLEY, CB ;
ANDREWS, WH ;
GREIDER, CW ;
VILLEPONTEAU, B .
SCIENCE, 1995, 269 (5228) :1236-1241
[7]   Short dysfunctional telomeres impair tumorigenesis in the INK4aΔ2/3 cancer-prone mouse [J].
Greenberg, RA ;
Chin, L ;
Femino, A ;
Lee, KH ;
Gottlieb, GJ ;
Singer, RH ;
Greider, CW ;
DePinho, RA .
CELL, 1999, 97 (04) :515-525
[8]   TELOMERES SHORTEN DURING AGING OF HUMAN FIBROBLASTS [J].
HARLEY, CB ;
FUTCHER, AB ;
GREIDER, CW .
NATURE, 1990, 345 (6274) :458-460
[9]  
HARLEY CB, 1995, TELOMERES
[10]   HUMAN TELOMERES - FUSION AND INTERSTITIAL SITES [J].
HASTIE, ND ;
ALLSHIRE, RC .
TRENDS IN GENETICS, 1989, 5 (10) :326-331