Increased levels of endothelial haemostatic markers in patients with coronary heart disease

被引：36

作者：

Schumacher, A

Seljeflot, I

Sommervoll, L

Christensen, B

Otterstad, JE

Arnesen, H

机构：

[1] Vestfold Cent Hosp, Dept Microbiol, N-3103 Tonsberg, Norway

[2] Vestfold Cent Hosp, Dept Med, N-3103 Tonsberg, Norway

[3] Ulleval Univ Hosp, Ctr Clin Res, Oslo, Norway

[4] Ulleval Univ Hosp, Dept Med Genet, Oslo, Norway

来源：

THROMBOSIS RESEARCH | 2002年 / 105卷 / 01期

关键词：

von Willebrand factor; thrombomodulin; tissue plasminogen activator; coronary heart disease;

D O I：

10.1016/S0049-3848(01)00399-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

von Willebrand factor (vWF), thrombomodulin and tissue plasminogen activator antigen (tPAag) are regarded as markers of endothelial activation and/or damage. Elevated levels have been associated with atherosclerotic disease states. The aim of the present study was to compare the levels of vWF, thrombomodulin and tPAag in patients with coronary heart disease (CHD) and matched healthy individuals to see if they discriminated significantly between the study groups also after adjustment for established CHD risk factors. Patients (n = 193) in various stages of CHD and matched controls (n = 193) were included. To evaluate possible influence of acute phase reaction, reinvestigation was performed alter 6 months. We observed elevated levels of vWF (P<.001) and tPAag (P<.001) but not thrombomodulin (P=.082) in CHD patients when compared to controls, still statistically significant after 6 months and also after adjustment for established risk factors. Our results indicate that vWF and tPAag but not thrombomodulin in the present population are independent markers of atherosclerosis. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：25 / 31

页数：7

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