Functional conservation of hematopoietic factors in Drosophila and vertebrates

被引：55

作者：

Fossett, N ^{[1
]}

Schulz, RA ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Grad Program Genes & Dev, Dept Biochem & Mol Biol, Houston, TX 77030 USA

来源：

DIFFERENTIATION | 2001年 / 69卷 / 2-3期

关键词：

GATA; friend of GATA; Runx; serpent; U-shaped lozenge;

D O I：

10.1046/j.1432-0436.2001.690202.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The GATA, Friend of GATA, and Runt homology domain protein families function during hematopoiesis to promote progenitor cell development and regulate lineage commitment and differentiation. The hematopoietic functions of these factors have been remarkably conserved across taxonomic groups, ranging from flies to humans. Furthermore, aspects of hematopoiesis and hemocyte function appear to be conserved. Thus, comparative studies using Drosophila and vertebrate models should enhance our understanding of blood cell development.

引用

页码：83 / 90

页数：8

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