Cloning and characterization of murine endothelial constitutive nitric oxide synthase

被引：44

作者：

Gnanapandithen, K

Chen, ZQ

Kau, CL

Gorczynski, RM

Marsden, PA

机构：

[1] UNIV TORONTO,ST MICHAELS HOSP,DIV RENAL,TORONTO,ON M5S 1A8,CANADA

[2] UNIV TORONTO,ST MICHAELS HOSP,DEPT MED,TORONTO,ON M5S 1A8,CANADA

[3] UNIV TORONTO,DEPT IMMUNOL,TORONTO,ON,CANADA

[4] UNIV TORONTO,DEPT SURG,TORONTO,ON,CANADA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1996年 / 1308卷 / 02期

基金：

英国医学研究理事会;

关键词：

endothelium; nitric oxide; vascular tone; hypertension; gene regulation;

D O I：

10.1016/0167-4781(96)00098-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complementary DNA clones encoding mouse endothelial constitutive nitric oxide synthase (ecNOS) were isolated by plaque hybridization from a murine fetal cardiac lambda ZAP II cDNA expression library using a full-length human ecNOS cDNA as the hybridization probe. DNA sequence analysis indicates a 1202 amino acid protein showing significant sequence identity with human as well as bovine ecNOS.

引用

页码：103 / 106

页数：4

共 20 条

[1]

BAEK KJ, 1993, J BIOL CHEM, V268, P21120

[2]

CHARTRAIN NA, 1994, J BIOL CHEM, V269, P6765

[3]

CHEN PF, 1994, J BIOL CHEM, V269, P25062

[4]

DUMONT DJ, 1993, ONCOGENE, V8, P1293