Trauma-induced coagulopathy

被引：18

作者：

Hanke, A. A. ^{[1
]}

Rahe-Meyer, N. ^{[2
]}

机构：

[1] Hannover Med Sch, Klin Anasthesiol & Intens Med, D-30625 Hannover, Germany

[2] Franziskus Hosp Bielefeld, Klin Anasthesiol & Operat Intens Med, Bielefeld, Germany

来源：

UNFALLCHIRURG | 2014年 / 117卷 / 02期

关键词：

Multiple trauma; Pathophysiology; Coagulation factors; Protein C; Hypothermia; DILUTIONAL COAGULOPATHY; BLOOD-LOSS; HYPOTHERMIA; COAGULATION; RESUSCITATION; IMPAIRMENT; REVERSAL; ACIDOSIS; PATIENT; INJURY;

D O I：

10.1007/s00113-013-2488-9

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The main cause of death in the patient group less than 45 years is trauma. Beside severe traumatic brain injury, bleeding remains a leading cause of death in this group. For a causal therapy, it is necessary to understand the pathophysiology of trauma-induced coagulopathy (TIC). Beside the well-known lethal triad of trauma (hypothermia, acidosis, and coagulopathy), dilution and hypoperfusion with activation of the protein C pathway play a crucial role. TIC is a complex independent syndrome which may be present without initial hypercoagulopathy. A rapid and differentiated diagnosis and goal-directed therapy is crucial for causal therapy.

引用

页码：95 / 98

页数：4

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