Trauma-induced coagulopathy

被引:18
作者
Hanke, A. A. [1 ]
Rahe-Meyer, N. [2 ]
机构
[1] Hannover Med Sch, Klin Anasthesiol & Intens Med, D-30625 Hannover, Germany
[2] Franziskus Hosp Bielefeld, Klin Anasthesiol & Operat Intens Med, Bielefeld, Germany
来源
UNFALLCHIRURG | 2014年 / 117卷 / 02期
关键词
Multiple trauma; Pathophysiology; Coagulation factors; Protein C; Hypothermia; DILUTIONAL COAGULOPATHY; BLOOD-LOSS; HYPOTHERMIA; COAGULATION; RESUSCITATION; IMPAIRMENT; REVERSAL; ACIDOSIS; PATIENT; INJURY;
D O I
10.1007/s00113-013-2488-9
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The main cause of death in the patient group less than 45 years is trauma. Beside severe traumatic brain injury, bleeding remains a leading cause of death in this group. For a causal therapy, it is necessary to understand the pathophysiology of trauma-induced coagulopathy (TIC). Beside the well-known lethal triad of trauma (hypothermia, acidosis, and coagulopathy), dilution and hypoperfusion with activation of the protein C pathway play a crucial role. TIC is a complex independent syndrome which may be present without initial hypercoagulopathy. A rapid and differentiated diagnosis and goal-directed therapy is crucial for causal therapy.
引用
收藏
页码:95 / 98
页数:4
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