Anti-atherosclerotic mechanisms of statin therapy

被引：49

作者：

Babelova, Andrea ^{[1
]}

Sedding, Daniel G. ^{[2
]}

Brandes, Ralf P. ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Kardiovaskulare Physiol, D-60054 Frankfurt, Germany

[2] Univ Giessen, Dept Cardiol, D-35390 Giessen, Germany

来源：

CURRENT OPINION IN PHARMACOLOGY | 2013年 / 13卷 / 02期

关键词：

HMG-COA REDUCTASE; KRUPPEL-LIKE FACTOR-2; ENDOTHELIAL FUNCTION; HYPERCHOLESTEROLEMIC HUMANS; CARDIOVASCULAR-DISEASE; TRANSCRIPTION FACTOR; RANDOMIZED-TRIALS; UP-REGULATION; IN-VITRO; ATORVASTATIN;

D O I：

10.1016/j.coph.2013.01.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

HMG-CoA-Reductase inhibitors, also known as statins, are currently the most powerful cholesterol-lowering drugs available on the market. Clinical trials and experimental evidence suggest that statins have anti-atherosclerotic effects. These are in part consequence of lipid lowering but also result from pleiotropic actions of the drugs. In this article, the anti-atherosclerotic actions of statins will be reviewed.

引用

页码：260 / 264

页数：5

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