Fragmentation and Unpredictability of Early-Life Experience in Mental Disorders

被引：199

作者：

Baram, Tallie Z. ^{[1
]}

Davis, Elysia P.

Obenaus, Andre

Sandman, Curt A.

Small, Steven L.

Solodkin, Ana

Stern, Hal

机构：

[1] Univ Calif Irvine, Sch Med, Dept Pediat, Irvine, CA 92717 USA

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2012年 / 169卷 / 09期

基金：

美国国家科学基金会;

关键词：

PITUITARY-ADRENAL AXIS; INFANT-MOTHER ATTACHMENT; MATERNAL-CARE; MESSENGER-RNA; IMMATURE RAT; STRESS; BEHAVIOR; EXPRESSION; MODEL; BRAIN;

D O I：

10.1176/appi.ajp.2012.11091347

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Maternal sensory signals in early life play a crucial role in programming the structure and function of the developing brain, promoting vulnerability or resilience to emotional and cognitive disorders. In rodent models of early-life stress, fragmentation and unpredictability of maternally derived sensory signals provoke persistent cognitive and emotional dysfunction in offspring. Similar variability and inconsistency of maternal signals during both gestation and early postnatal human life may influence development of emotional and cognitive functions, including those that underlie later depression and anxiety.

引用

页码：907 / 915

页数：9

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