Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

被引：713

作者：

Tapon, N ^{[1
]}

Hall, A ^{[1
]}

机构：

[1] UCL, DEPT BIOCHEM, LONDON WC1E 6BT, ENGLAND

来源：

CURRENT OPINION IN CELL BIOLOGY | 1997年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0955-0674(97)80156-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rho, Rac and Cdc42 are three Ras-related GTP-binding proteins that control the assembly and disassembly of the actin cytoskeleton in response to extracellular signals. During the past year, numerous candidate downstream targets for these GTPases have been identified using affinity chromatography and yeast two-hybrid techniques. These techniques have revealed that Rho regulates the myosin light chain phosphatase and that Rho and Rac control the synthesis of phosphatidylinositol 4,5-bisphosphate, two activities that might help to explain the effects of these GTPases on the actin cytoskeleton.

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页码：86 / 92

页数：7

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