Mechanisms by which thiazolidinediones enhance insulin action

被引：83

作者：

Reginato, MJ

Lazar, MA

机构：

[1] Univ Penn, Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA

[2] Univ Penn, Med Ctr, Penn Diabet Ctr, Philadelphia, PA 19104 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1043-2760(98)00110-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thiazolidinediones (TZDs) are an exciting new class of insulin-sensitizing drugs being used currently for the treatment of non-insulin-dependent diabetes mellitus. The molecular target of these compounds is thought to be the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPAR gamma). PPAR gamma is expressed predominantly in adipose tissue, yet a major site of TZD-responsive glucose disposal is skeletal muscle. Potential explanations for this paradox are discussed in this review.

引用

收藏

页码：9 / 13

页数：5

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