Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups

被引：34

作者：

Akkad, DA

Jagiello, P

Szyld, P

Goedde, R

Wieczorek, S

Gross, WL

Epplen, JT ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Dept Human Genet, D-44801 Bochum, Germany

[2] Univ Hosp Luebeck, Dept Rheumatol, Lubeck, Germany

[3] Rheumaklin Bad Bramstedt, D-24576 Bad Bramstedt, Germany

来源：

INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2006年 / 33卷 / 01期

关键词：

D O I：

10.1111/j.1744-313X.2006.00568.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We analysed whether the single nucleotide polymorphism (SNP) rs3087456 in the promoter of the MHC class II transactivator (MHC2TA) gene is associated with manifestation of rheumatoid arthritis, multiple sclerosis, narcolepsy and Wegener granulomatosis. The recently reported association in a northern population of the MHC2TA variation with these autoimmune diseases is not evident in the German population.

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页码：59 / 61

页数：3

相关论文

共 13 条

[1] The genetics of narcolepsy [J].

Chabas, D ;

Taheri, S ;

Renier, C ;

Mignot, E .

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2003, 4 :459-483

[2] GPOWER: A general power analysis program [J].

Erdfelder, E ;

Faul, F ;

Buchner, A .

BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS, 1996, 28 (01) :1-11

[3] MHC II molecules in inflammatory diseases: interplay of qualities and quantities [J].

Friese, MA ;

Jones, EY ;

Fugger, L .

TRENDS IN IMMUNOLOGY, 2005, 26 (11) :559-561

[4] Association of the HLA region with multiple sclerosis as confirmed by a genome screen using > 10,000 SNPs on DNA chips [J].

Gödde, R ;

Rohde, K ;

Becker, C ;

Toliat, MR ;

Entz, P ;

Suk, A ;

Müller, N ;

Sindern, E ;

Haupts, M ;

Schimrigk, S ;

Nürnberg, P ;

Epplen, JT .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2005, 83 (06) :486-494

[5] A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers [J].

Goedde, R ;

Sawcer, S ;

Boehringer, S ;

Miterski, B ;

Sindern, E ;

Haupts, M ;

Schimrigk, S ;

Compston, A ;

Epplen, JT .

HUMAN GENETICS, 2002, 111 (03) :270-277

[6]

GOEDDE R, 2004, RECENT RES DEV HUMAN, V2, P183

[7] Association study of Wegener granulomatosis and the functionally relevant A645G polymorphism in the bactericidal/permeability increasing protein (BPI) gene [J].

Jagiello, P ;

Klein, W ;

Schultz, H ;

Csernok, E ;

Gross, WL ;

Epplen, JT .

INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2005, 32 (01) :3-6

[8] New genomic region for Wegener's granulomatosis as revealed by an extended association screen with 202 apoptosis-related genes [J].

Jagiello, P ;

Gencik, M ;

Arning, L ;

Wieczorek, S ;

Kunstmann, E ;

Csernok, E ;

Gross, WL ;

Epplen, JT .

HUMAN GENETICS, 2004, 114 (05) :468-477

[9] How T cells 'see' antigen [J].

Krogsgaard, M ;

Davis, MM .

NATURE IMMUNOLOGY, 2005, 6 (03) :239-245

[10] Specificity and expression of CIITA, the master regulator of MHC class II genes [J].

LeibundGut-Landmann, S ;

Waldburger, JM ;

Krawczyk, M ;

Otten, LA ;

Suter, T ;

Fontana, A ;

Acha-Orbea, H ;

Reith, W .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (06) :1513-1525