The importance of inflammatory mechanisms for the development of Alzheimer's disease

被引：30

作者：

Eikelenboom, P ^{[1
]}

Veerhuis, R ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Neurosci Res Inst, Grad Sch Neurosci, Dept Psychiat,Valeriusklin, NL-1075 BG Amsterdam, Netherlands

来源：

EXPERIMENTAL GERONTOLOGY | 1999年 / 34卷 / 03期

关键词：

Alzheimer's disease; delirium; inflammation; activated microglia; acute phase response;

D O I：

10.1016/S0531-5565(99)00022-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

A variety of inflammatory proteins has been identified in brains. of patients with Alzheimer's disease, The current data suggest that the inflammatory processes are intimately involved in several crucial events in the pathological cascade, Immunohistochemical studies reveal that those parts of the brain wherein the amyloid-beta deposits are closely associated with a chronic inflammatory response are strongly related to the characteristic symptoms, An inflammation-based approach could also provide a valuable theoretical framework to study the influence of extracerebral factors (such as acute phase reactants) on the clinical course of Alzheimer's disease, (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：453 / 461

页数：9

共 38 条

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