Second-generation microstimulator

被引：22

作者：

Arcos, I ^{[1
]}

Davis, R ^{[1
]}

Fey, K ^{[1
]}

Mishler, D ^{[1
]}

Sanderson, D ^{[1
]}

Tanacs, C ^{[1
]}

Vogel, MJ ^{[1
]}

Wolf, R ^{[1
]}

Zilberman, Y ^{[1
]}

Schulman, J ^{[1
]}

机构：

[1] Alfred E Mann Fdn, Valencia, CA 91355 USA

来源：

ARTIFICIAL ORGANS | 2002年 / 26卷 / 03期

关键词：

animal experiment; BION; injectable implantable microstimulator;

D O I：

10.1046/j.1525-1594.2002.06938.x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The first-generation injectable microstimulator was glass encased with an external tantalum capacitor electrode. This second-generation device uses a hermetically sealed ceramic case with platinum electrodes. Zener diodes protect the electronics from defibrillation shocks and from electrostatic discharge. The capacitor is sealed inside the case so that it cannot be inadvertently damaged by surgical instruments. This microstimulator, referred to as BION, is the main component of a 255-channel wireless stimulating system. BION devices have been implanted in rats for periods of up to 5 months. Results show benign tissue reactions resulting in identical encapsulation around BION and controls. Stimulation threshold levels did not change significantly over time and ranged between 0.81 to 1.35 mA for all the animals at a 60 mus pulse width. All of the tests performed to date indicate that the BION is safe and effective for long-term human implant. We have elected to develop BION applications by seeking collaboration with the research community through our BION Technology Partnership.

引用

页码：228 / 231

页数：4

共 7 条

[1] Long-term biocompatibility of a miniature stimulator implanted in feline hind limb muscles [J].