Novel applications of recombinant erythropoietin

被引：33

作者：

Sharples, EJ ^{[1
]}

Thiemermann, C ^{[1
]}

Yaqoob, MM ^{[1
]}

机构：

[1] Univ London, Queen Mary, William Harvey Res Inst, Ctr Expt Med Nephrol & Crit Care, Charterhouse Sq, London EC1M 6BQ, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2006年 / 6卷 / 02期

关键词：

D O I：

10.1016/j.coph.2006.01.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recombinant erythropoietin (EPO) was introduced into clinical practice after the identification of EPO as the major haemopoietic growth factor determining survival and maturation of erthyroid precursors. Advances in our understanding of the novel sites of action of EPO in the vasculature, brain, heart and kidney have opened new avenues of therapeutic potential for EPO, and have led to an increased understanding of the biological roles of EPO and its mechanisms of cell protection.

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页码：184 / 189

页数：6

相关论文

共 56 条

[1] Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia [J].

Abdelrahman, M ;

Sharples, EJ ;

McDonald, MC ;

Collin, M ;

Patel, NSA ;

Yaqoob, MM ;

Thiemermann, C .

SHOCK, 2004, 22 (01) :63-69

[2] ERYTHROPOIETIN HAS A MITOGENIC AND POSITIVE CHEMOTACTIC EFFECT ON ENDOTHELIAL-CELLS [J].

ANAGNOSTOU, A ;

LEE, ES ;

KESSIMIAN, N ;

LEVINSON, R ;

STEINER, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) :5978-5982

[3] Adult skeletal muscle stem cells differentiate into endothelial lineage and ameliorate renal dysfunction after acute ischemia [J].

Arriero, M ;

Brodsky, SV ;

Gealekman, O ;

Lucas, PA ;

Goligorsky, MS .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2004, 287 (04) :F621-F627

[4] Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure [J].

Bahlmann, FH ;

Song, R ;

Boehm, SM ;

Mengel, M ;

von Wasielewski, R ;

Lindschau, C ;

Kirsch, T ;

de Groot, K ;

Laudeley, R ;

Niemczyk, E ;

Güler, F ;

Menne, J ;

Haller, H ;

Fliser, D .

CIRCULATION, 2004, 110 (08) :1006-1012

[5] Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin - Rapid communication [J].

Bahlmann, FH ;

DeGroot, K ;

Duckert, T ;

Niemczyk, E ;

Bahlmann, E ;

Boehm, SM ;

Haller, H ;

Fliser, D .

KIDNEY INTERNATIONAL, 2003, 64 (05) :1648-1652

[6] Neuroprotective effect of darbepoetin alfa, a novel recombinant erythropoietic protein, in focal cerebral ischemia in rats [J].

Belayev, L ;

Khoutorova, L ;

Zhao, WZ ;

Vigdorchik, A ;

Belayev, A ;

Busto, R ;

Magal, E ;

Ginsberg, MD .

STROKE, 2005, 36 (05) :1065-1070

[7] A potential role for erythropoietin in focal permanent cerebral ischemia in mice [J].

Bernaudin, M ;

Marti, HH ;

Roussel, S ;

Divoux, D ;

Nouvelot, A ;

MacKenzie, E ;

Petit, E .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1999, 19 (06) :643-651

[8] Erythropoietin mediates tissue protection through an erythropoietin and common β-subunit heteroreceptor [J].

Brines, M ;

Grasso, G ;

Fiordaliso, F ;

Sfacteria, A ;

Ghezzi, P ;

Fratelli, M ;

Latini, R ;

Xie, QW ;

Smart, J ;

Su-Rick, CJ ;

Pobre, E ;

Diaz, D ;

Gomez, D ;

Hand, C ;

Coleman, T ;

Cerami, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (41) :14907-14912

[9] Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury [J].

Brines, ML ;

Ghezzi, P ;

Keenan, S ;

Agnello, D ;

de Lanerolle, NC ;

Cerami, C ;

Itri, LM ;

Cerami, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (19) :10526-10531

[10] Endothelial dysfunction in ischemic acute renal failure: rescue by transplanted endothelial cells [J].

Brodsky, SV ;

Yamamoto, T ;

Tada, T ;

Kim, B ;

Chen, J ;

Kajiya, F ;

Goligorsky, MS .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2002, 282 (06) :F1140-F1149

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