Laser-induced fluorescence-cued, laser-induced breakdown spectroscopy biological-agent detection

被引:34
作者
Hybl, John D. [1 ]
Tysk, Shane M. [1 ]
Berry, Shaun R. [1 ]
Jordan, Michael P. [1 ]
机构
[1] MIT, Lincoln Lab, Lexington, MA 02420 USA
关键词
D O I
10.1364/AO.45.008806
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Methods for accurately characterizing aerosols are required for detecting biological warfare agents. Currently, fluorescence-based biological agent sensors provide adequate detection sensitivity but suffer from high false-alarm rates. Combining single-particle fluorescence analysis with laser-induced breakdown spectroscopy (LIBS) provides additional discrimination and potentially reduces false-alarm rates. A transportable UV laser-induced fluorescence-cued LIBS test bed has been developed and used to evaluate the utility of LIBS for biological-agent detection. Analysis of these data indicates that LIBS adds discrimination capability to fluorescence-based biological-agent detectors. However, the data also show that LIBS signatures of biological agent simulants are affected by washing. This may limit the specificity of LIBS and narrow the scope of its applicability in biological-agent detection. (c) 2006 Optical Society of America.
引用
收藏
页码:8806 / 8814
页数:9
相关论文
共 25 条
[1]  
[Anonymous], BACTERIAL SPORE
[2]   Prospects of real-time single-particle biological aerosol analysis: A comparison between laser-induced breakdown spectroscopy and aerosol time-of-flight mass spectrometry [J].
Beddows, DCS ;
Telle, HH .
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY, 2005, 60 (7-8) :1040-1059
[3]   Single-pollen analysis by laser-induced breakdown spectroscopy and Raman microscopy [J].
Boyain-Goitia, AR ;
Beddows, DCS ;
Griffiths, BC ;
Telle, HH .
APPLIED OPTICS, 2003, 42 (30) :6119-6132
[4]   On-line analysis of ambient air aerosols using laser-induced breakdown spectroscopy [J].
Carranza, JE ;
Fisher, BT ;
Yoder, GD ;
Hahn, DW .
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY, 2001, 56 (06) :851-864
[5]   Feasibility of detection and identification of individual bioaerosols using laser-induced breakdown spectroscopy [J].
Dixon, PB ;
Hahn, DW .
ANALYTICAL CHEMISTRY, 2005, 77 (02) :631-638
[6]   Effects of aerosols and laser cavity seeding on spectral and temporal stability of laser-induced plasmas: applications to LIBS [J].
Hohreiter, V ;
Ball, AJ ;
Hahn, DW .
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, 2004, 19 (10) :1289-1294
[7]   Laser-induced breakdown spectroscopy detection and classification of biological aerosols [J].
Hybl, JD ;
Lithgow, GA ;
Buckley, SG .
APPLIED SPECTROSCOPY, 2003, 57 (10) :1207-1215
[8]  
Jaenicke R., 1993, TROPOSPHERIC AEROSOL, P1, DOI DOI 10.1016/S0074-6142(08)60210-7
[9]   Spectral fingerprints of bacterial strains by laser-induced breakdown spectroscopy [J].
Kim, T ;
Specht, ZG ;
Vary, PS ;
Lin, CT .
JOURNAL OF PHYSICAL CHEMISTRY B, 2004, 108 (17) :5477-5482
[10]   Effects of focal volume and spatial inhomogeneity on uncertainty in single-aerosol laser-induced breakdown spectroscopy measurements [J].
Lithgow, GA ;
Buckley, SG .
APPLIED PHYSICS LETTERS, 2005, 87 (01)