Comparative genetics of type 1 diabetes and autoimmune disease - Common loci, common pathways?

被引：106

作者：

Becker, KG ^{[1
]}

机构：

[1] NIA, Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA

来源：

DIABETES | 1999年 / 48卷 / 07期

关键词：

D O I：

10.2337/diabetes.48.7.1353

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genome-scale analysis in type 1 diabetes has resulted in a number of non-major histocompatibility complex loci of varying levels of statistical significance. In no case has a specific gene been proven to be the source of genetic linkage at any candidate locus. Comparative analysis of the position of loci for type 1 diabetes with candidate loci from other autoimmune/inflammatory diseases shows considerable overlap. This supports a hypothesis that the underlying genetic susceptibility to type 1 diabetes may be shared with other clinically distinct autoimmune diseases such as systemic lupus erythemastosus, multiple sclerosis, and Crohn's Disease.

引用

页码：1353 / 1358

页数：6

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