Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

被引：1109

作者：

Moore, Kevin W. ^{[1
]}

Vieira, Paulo ^{[1
]}

Fiorentino, David F. ^{[1
]}

Trounstine, Mary L. ^{[1
]}

Khan, Tariq A. ^{[1
]}

Mosmann, Timothy R. ^{[1
]}

机构：

[1] DNAX Res Inst Molec & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

来源：

JOURNAL OF IMMUNOLOGY | 2012年 / 189卷 / 05期

关键词：

T-CELL CLONE; FC-RECEPTOR; LEISHMANIA-TROPICA; INTERFERON-GAMMA; MESSENGER-RNA; DNA-SEQUENCE; TH2; CLONES; IFN-GAMMA; B-CELLS; ANTIGEN;

D O I：

10.1126/science.2161559

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Complementary DNA clones encoding mouse cytokines synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis T(H)l helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.

引用

页码：1230 / 1234

页数：5

共 48 条

[1] DNA-SEQUENCE AND EXPRESSION OF THE B95-8 EPSTEIN-BARR VIRUS GENOME [J].

BAER, R ;

BANKIER, AT ;

BIGGIN, MD ;

DEININGER, PL ;

FARRELL, PJ ;

GIBSON, TJ ;

HATFULL, G ;

HUDSON, GS ;

SATCHWELL, SC ;

SEGUIN, C ;

TUFFNELL, PS ;

BARRELL, BG .

NATURE, 1984, 310 (5974) :207-211

[2] HUMAN CYTOMEGALO-VIRUS ENCODES A GLYCOPROTEIN HOMOLOGOUS TO MHC CLASS-I ANTIGENS [J].

BECK, S ;

BARRELL, BG .

NATURE, 1988, 331 (6153) :269-272

[3] HETEROGENEITY OF HELPER INDUCER LYMPHOCYTES-T .2. EFFECTS OF INTERLEUKIN-4-PRODUCING AND INTERLEUKIN-2-PRODUCING T-CELL CLONES ON RESTING LYMPHOCYTES-B [J].

BOOM, WH ;

LIANO, D ;

ABBAS, AK .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (04) :1350-1363

[4] B-CELL STIMULATORY FACTOR-I INTERLEUKIN-4 MESSENGER-RNA IS EXPRESSED BY NORMAL AND TRANSFORMED MAST-CELLS [J].

BROWN, MA ;

PIERCE, JH ;

WATSON, CJ ;

FALCO, J ;

IHLE, JN ;

PAUL, WE .

CELL, 1987, 50 (05) :809-818

[5]

CHER DJ, 1987, J IMMUNOL, V138, P3688

[6] 2 TYPES OF MOUSE HELPER T-CELL CLONE .3. FURTHER DIFFERENCES IN LYMPHOKINE SYNTHESIS BETWEEN TH1 AND TH2 CLONES REVEALED BY RNA HYBRIDIZATION, FUNCTIONALLY MONOSPECIFIC BIOASSAYS, AND MONOCLONAL-ANTIBODIES [J].

CHERWINSKI, HM ;

SCHUMACHER, JH ;

BROWN, KD ;

MOSMANN, TR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (05) :1229-1244

[7]

COFFMAN RL, 1986, J IMMUNOL, V136, P4538

[8] ANTIBODY TO INTERLEUKIN-5 INHIBITS HELMINTH-INDUCED EOSINOPHILIA IN MICE [J].

COFFMAN, RL ;

SEYMOUR, BWP ;

HUDAK, S ;

JACKSON, J ;

RENNICK, D .

SCIENCE, 1989, 245 (4915) :308-310

[9] THE COMPLETE DNA-SEQUENCE OF VARICELLA-ZOSTER VIRUS [J].

DAVISON, AJ ;

SCOTT, JE .

JOURNAL OF GENERAL VIROLOGY, 1986, 67 :1759-1816

[10]

DELPRETE G, 1988, J IMMUNOL, V140, P4193

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