Effects of PPARγ agonists on the expression of leptin and vascular endothelial growth factor in breast cancer cells

被引：34

作者：

Terrasi, Marianna ^{[1
]}

Bazan, Viviana ^{[1
]}

Caruso, Stefano ^{[1
]}

Insalaco, Lavinia ^{[1
]}

Amodeo, Valeria ^{[1
]}

Fanale, Daniele ^{[1
]}

Corsini, Lidia Rita ^{[1
]}

Contaldo, Clara ^{[2
]}

Mercanti, Anna ^{[2
]}

Fiorio, Elena ^{[2
]}

Lo Re, Giuseppe ^{[3
]}

Cicero, Giuseppe ^{[1
]}

Surmacz, Eva ^{[2
]}

Russo, Antonio ^{[1
]}

机构：

[1] Univ Palermo, Sect Med Oncol, Dept Surg & Oncol Sci, I-90127 Palermo, Italy

[2] Temple Univ, Sbarro Inst Canc Res & Mol Med, Philadelphia, PA 19122 USA

[3] Univ Palermo, Dept Radiol, DIBIMEF, Palermo, Italy

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2013年 / 228卷 / 06期

关键词：

ACTIVATED-RECEPTOR-GAMMA; BLADDER-CANCER; IN-VITRO; DIABETIC-PATIENTS; GENE-EXPRESSION; VEGF; PIOGLITAZONE; THIAZOLIDINEDIONES; TRANSACTIVATION; ROSIGLITAZONE;

D O I：

10.1002/jcp.24295

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The obesity hormone leptin has been implicated in breast cancer development. Breast cancer cells express the leptin receptor and are able to synthesize leptin in response to obesity-related stimuli. Furthermore, leptin is a positive regulator of vascular endothelial growth factor (VEGF) and high levels of both proteins are associated with worse prognosis in breast cancer patients. Peroxisome proliferator-activated receptor (PPAR) ligands are therapeutic agents used in patient with Type 2 diabetes and obesity which have recently been studied for their potential anti-tumor effect. Here, we studied if these compounds, ciglitazone and GW1929, can affect the expression of leptin and VEGF in breast cancer cells. In MDA-MB-231 and MCF-7 breast cancer cells, treatment with submolar concentrations of ciglitazone and GW1929 elevated the expression of leptin and VEGF mRNA and protein, and increased cell viability and migration. These effects coincided with increased recruitment of PPAR to the proximal leptin promoter and decreased association of a transcriptional factor Sp1 with this DNA region. J. Cell. Physiol. 228: 13681374, 2013. (c) 2012 Wiley Periodicals, Inc.

引用

页码：1368 / 1374

页数：7

共 46 条

[1] Human leptin induces angiogenesis in vivo [J].

Anagnostoulis, Stavros ;

Karayiannakis, Anastasios J. ;

Lambropoulou, Maria ;

Efthimiadou, Anna ;

Polychronidis, Alexandros ;

Simopoulos, Constantinos .

CYTOKINE, 2008, 42 (03) :353-357

[2] Insulin-dependent leptin expression in breast cancer cells [J].

Bartella, Viviana ;

Cascio, Sandra ;

Fiorio, Elena ;

Auriemma, Alessandra ;

Russo, Antonio ;

Surmacz, Eva .

CANCER RESEARCH, 2008, 68 (12) :4919-4927

[3] Relative effects of VEGF-A and VEGF-C on endothelial cell proliferation, migration, and PAF synthesis: Role of neuropilin-1 [J].

Bernatchez, PN ;

Rollin, S ;

Soker, S ;

Sirois, MG .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2002, 85 (03) :629-639

[4] Selective activation of peroxisome proliferator-activated receptor (PPAR)α and PPARγ induces neoangiogenesis through a vascular endothelial growth factor-dependent mechanism [J].

Biscetti, Federico ;

Gaetani, Eleonora ;

Flex, Andrea ;

Aprahamian, Tamar ;

Hopkins, Teresa ;

Straface, Giuseppe ;

Pecorini, Giovanni ;

Stigliano, Egidio ;

Smith, Roy C. ;

Angelini, Flavia ;

Castellot, John J., Jr. ;

Pola, Roberto .

DIABETES, 2008, 57 (05) :1394-1404

[5] Use of the peroxisome proliferator-activated receptor (PPAR) γ ligand troglitazone as treatment for refractory breast cancer:: a phase II study [J].

Burstein, HJ ;

Demetri, GD ;

Mueller, E ;

Sarraf, P ;

Spiegelman, BM ;

Winer, EP .

BREAST CANCER RESEARCH AND TREATMENT, 2003, 79 (03) :391-397

[6] Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF [J].

Cao, RH ;

Brakenhielm, E ;

Wahlestedt, C ;

Thyberg, J ;

Cao, YH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (11) :6390-6395

[7] RETRACTED ARTICLE: Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1α [J].

S Cascio ;

V Bartella ;

A Auriemma ;

G J Johannes ;

A Russo ;

A Giordano ;

E Surmacz .

Oncogene, 2008, 27 (4) :540-547

[8] PPAR-γ ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo [J].

Choi, I. K. ;

Kim, Y. H. ;

Kim, J. S. ;

Seo, J. H. .

INVESTIGATIONAL NEW DRUGS, 2008, 26 (03) :283-288

[9] Regulation of VEGF/VPF expression in tumor cells: Consequences for tumor growth and metastasis [J].

Claffey, KP ;

Robinson, GS .

CANCER AND METASTASIS REVIEWS, 1996, 15 (02) :165-176

[10] Magnitude of peroxisome proliferator-activated receptor-γ activation is associated with important and seemingly opposite biological responses in breast cancer cells [J].

Clay, CE ;

Namen, AM ;

Atsumi, G ;

Trimboli, AJ ;

Fonteh, AN ;

High, KP ;

Chilton, FH .

JOURNAL OF INVESTIGATIVE MEDICINE, 2001, 49 (05) :413-420

← 1 2 3 4 5 →