Dopamine in neurotoxicity and neuroprotection:: what do D2 receptors have to do with it?

被引：143

作者：

Bozzi, Y

Borrelli, E ^{[1
]}

机构：

[1] ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Strasbourg, France

[2] CNR, Ist Neurosci, I-56100 Pisa, Italy

来源：

TRENDS IN NEUROSCIENCES | 2006年 / 29卷 / 03期

关键词：

D O I：

10.1016/j.tins.2006.01.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Accurate control of dopamine levels and/or the resulting dopamine-receptor interaction is essential for brain function. Indeed, several human neurological and psychiatric disorders are characterized by dysfunctions of the dopaminergic system. Dopamine has been reported to exert either protective or toxic effects on neurons, yet it is unclear whether these effects are receptor-dependent and, if so, which dopamine receptor could be involved. The D-2 dopamine receptor occupies a privileged position because its signalling might be neuroprotective in human diseases, such as Parkinson's disease, ischaemia and epilepsy. Unravelling the role of D-2 receptors in neuronal death and survival might be central to understanding the mechanisms that underlie several neuropathologies.

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收藏

页码：167 / 174

页数：8

相关论文

共 79 条

[1] Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system [J].

Abeliovich, A ;

Schmitz, Y ;

Fariñas, I ;

Choi-Lundberg, D ;

Ho, WH ;

Castillo, PE ;

Shinsky, N ;

Verdugo, JMG ;

Armanini, M ;

Ryan, A ;

Hynes, M ;

Phillips, H ;

Sulzer, D ;

Rosenthal, A .

NEURON, 2000, 25 (01) :239-252

[2] DOPAMINE-INDUCED PROTECTION OF STRIATAL NEURONS AGAINST KAINATE RECEPTOR-MEDIATED GLUTAMATE CYTOTOXICITY IN-VITRO [J].

AMANO, T ;

UJIHARA, H ;

MATSUBAYASHI, H ;

SASA, M ;

YOKOTA, T ;

TAMURA, Y ;

AKAIKE, A .

BRAIN RESEARCH, 1994, 655 (1-2) :61-69

[3]

Barzilai A, 2003, ADV NEUROL, V91, P73

[4] Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease [J].

Barzilai, A ;

Melamed, E .

TRENDS IN MOLECULAR MEDICINE, 2003, 9 (03) :126-132

[5] Is there a rationale for neuroprotection against dopamine toxicity in Parkinson's disease? [J].

Barzilai, A ;

Melamed, E ;

Shirvan, A .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2001, 21 (03) :215-235

[6] An Akt/β-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior [J].

Beaulieu, JM ;

Sotnikova, TD ;

Marion, S ;

Lefkowitz, RJ ;

Gainetdinov, RR ;

Caron, MG .

CELL, 2005, 122 (02) :261-273

[7] DOPAMINE NEUROTOXICITY - INHIBITION OF MITOCHONDRIAL RESPIRATION [J].

BENSHACHAR, D ;

ZUK, R ;

GLINKA, Y .

JOURNAL OF NEUROCHEMISTRY, 1995, 64 (02) :718-723

[8] Without DJ-1, the D2 receptor doesn't play [J].

Borrelli, E .

NEURON, 2005, 45 (04) :479-481

[9] Pharmaceuticals degradation by UV and UV/H2O2 treatments [J].

Bozzi, A ;

Lopez, A ;

Mascolo, G ;

Tiravantl, G .

2ND WORLD WATER CONGRESS: DRINKING WATER TREATMENT, 2002, 2 (02) :19-26

[10] Neuroprotective role of dopamine against hippocampal cell death [J].

Bozzi, Y ;

Vallone, D ;

Borrelli, E .

JOURNAL OF NEUROSCIENCE, 2000, 20 (22) :8643-8649

← 1 2 3 4 5 6 7 8 →