More hippocampal neurons in adult mice living in an enriched environment

被引：2718

作者：

Kempermann, G ^{[1
]}

Kuhn, HG ^{[1
]}

Gage, FH ^{[1
]}

机构：

[1] SALK INST BIOL STUDIES,GENET LAB,LA JOLLA,CA 92037

来源：

NATURE | 1997年 / 386卷 / 6624期

关键词：

D O I：

10.1038/386493a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neurogenesis occurs in the dentate gyrus of the hippocampus throughout the life of a rodent(1-4), but the function of these new neurons and the mechanisms that regulate their birth are unknown, Here we show that significantly more new neurons exist in the dentate gyrus of mice exposed to an enriched environment compared with littermates housed in standard cages. We also show, using unbiased stereology, that the enriched mice have a larger hippocampal granule cell layer and 15 per cent more granule cell neurons in the dentate gyrus.

引用

页码：493 / 495

页数：3

共 29 条

[1] AUTORADIOGRAPHIC AND HISTOLOGICAL EVIDENCE OF POSTNATAL HIPPOCAMPAL NEUROGENESIS IN RATS [J].