The IFN gamma receptor: A paradigm for cytokine receptor signaling

被引：843

作者：

Bach, EA

Aguet, M

Schreiber, RD

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110

[2] SWISS INST EXPT CANC RES,ISREC,CH-1066 EPALINGES,SWITZERLAND

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 1997年 / 15卷

关键词：

signal transduction; JAK-STAT pathway; transcription factors; tyrosine kinases; Stat1; HUMAN INTERFERON-GAMMA; PROTEIN-TYROSINE KINASES; MICE LACKING JAK3; TRANSCRIPTION FACTOR; ACCESSORY FACTOR; EXTRACELLULAR DOMAIN; MOLECULAR CHARACTERIZATION; LYMPHOID DEVELOPMENT; CRYSTAL-STRUCTURE; BINDING CAPACITY;

D O I：

10.1146/annurev.immunol.15.1.563

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the last several years, the mechanism of IFN gamma-dependent signal transduction has been the focus of intense investigation. This research has recently culminated in the elucidation of a comprehensive molecular understanding of the events that underlie IFN gamma-induced cellular responses. The structure and function of the IFN gamma receptor have been defined. The mechanism of IFN gamma signal transduction has been largely elucidated, and the physiologic relevance of this process validated. Most recently, the molecular events that link receptor ligation to signal transduction have been established. Together these insights have produced a model of IFN gamma signaling that is nearly complete and that serves as a paradigm for signaling by other members of the cytokine receptor superfamily.

引用

页码：563 / &

页数：30

共 107 条

[1] PURIFICATION OF HUMAN GAMMA-INTERFERON RECEPTORS BY SEQUENTIAL AFFINITY-CHROMATOGRAPHY ON IMMOBILIZED MONOCLONAL ANTIRECEPTOR ANTIBODIES AND HUMAN GAMMA-INTERFERON [J].