Interleukin-10 downregulates the intracerebral immune response in chronic Toxoplasma encephalitis

被引：46

作者：

DeckertSchluter, M ^{[1
]}

Buck, C ^{[1
]}

Weiner, D ^{[1
]}

Kaefer, N ^{[1
]}

Rang, A ^{[1
]}

Hof, H ^{[1
]}

Wiestler, OD ^{[1
]}

Schluter, D ^{[1
]}

机构：

[1] UNIV HEIDELBERG,KLINIKUM MANNHEIM,INST MED MIKROBIOL & HYG,MANNHEIM,GERMANY

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1997年 / 76卷 / 1-2期

关键词：

encephalitis; interleukin-10; Toxoplasma gondii;

D O I：

10.1016/S0165-5728(97)00047-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The expression of the immunosuppressive cytokine interleukin (IL)-10 in the normal and Toxoplasma gondii-infected murine brain was analysed. Microglia/macrophages expressed IL-10 at the mRNA and protein level in the normal brain. In Toxoplasma encephalitis (TE), CD4(+) and CD8(+) T-cells also contributed to the upregulated IL-10 production. Neutralization of endogenous IL-10 in chronic TE reduced the intracerebral parasitic load and increased the number of immune cells and the production of protective cytokines. These findings indicate that intracerebral expression of IL-10 interferes with the immune response in TE and may contribute to parasite persistence in the brain.

引用

页码：167 / 176

页数：10

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