Effect of the α2 adrenoreceptor antagonist, idazoxan, on motor disabilities in MPTP-treated monkey

被引：36

作者：

Bezard, E ^{[1
]}

Brefel, C

Tison, F

Peyro-Saint-Paul, H

Ladure, P

Rascol, O

Gross, CE

机构：

[1] Univ Bordeaux 2, Basal Gang, Neurophysiol Lab, CNRS,UMR 5543, F-33076 Bordeaux, France

[2] CHU Toulouse, Serv Pharmacol Clin, INSERM, U455, Toulouse, France

[3] Inst Rech Pierre Fabre, Labege Innopole, France

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1999年 / 23卷 / 07期

关键词：

alpha; 2; adrenoreceptor; idazoxan; L-dopa; monkey; MPTP; rigidity; Parkinson's disease;

D O I：

10.1016/S0278-5846(99)00067-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. The motor effect of the alpha 2 adrenoreceptor antagonist, idazoxan, was compared to that of L-dopa in MPTP-treated monkeys. 2. Idazoxan 2.0 mg/kg improved parkinsonian motor abnormalities which was comparable to the effects of a minimal effective dose of L-dopa. 3. At 2.0 and 5.0 mg/kg, the parkinsonian rigidity was the item most frequently alleviated by idazoxan (respectively 63.6% and 68.2%). 4. These findings provide support for the therapeutic utility of alpha 2 antagonists in the treatment of Parkinson's disease.

引用

页码：1237 / 1246

页数：10

共 33 条

[1]

Agid Y., 1987, MOVEMENT DISORD, V2, P166

[2] RILUZOLE PREVENTS MPTP-INDUCED PARKINSONISM IN THE RHESUS-MONKEY - A PILOT-STUDY [J].