Mechanism of the Sex Difference in Endothelial Dysfunction after Stroke

被引：43

作者：

Davis, Catherine M. ^{[1
]}

Fairbanks, Stacy L. ^{[1
]}

Alkayed, Nabil J. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Cerebrovasc Res Div, Dept Anesthesiol & Perioperat Med, Portland, OR 97239 USA

来源：

TRANSLATIONAL STROKE RESEARCH | 2013年 / 4卷 / 04期

关键词：

sEH; Ischemia; Endothelia; EET; Brain; Sexual dimorphism; SOLUBLE EPOXIDE HYDROLASE; EPOXYEICOSATRIENOIC ACID METABOLISM; ESTRADIOL-MEDIATED NEUROPROTECTION; ISCHEMIA-REPERFUSION INJURY; BLOOD-PRESSURE REGULATION; ESTROGEN-RECEPTOR-ALPHA; OBESE ZUCKER RATS; ARACHIDONIC-ACID; CEREBRAL-ISCHEMIA; THERAPEUTIC TARGET;

D O I：

10.1007/s12975-012-0227-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Stroke, the number four cause of death in the USA, is a greatly debilitating event resulting from insufficient blood supply to the brain (cerebral ischemia). Endothelial dysfunction, primarily characterized by dampened endothelial-dependent vasodilation, is a major contributor to the development and outcome of stroke. This review discusses the role of soluble epoxide hydrolase, an enzyme responsible for the degradation of vasoprotective epoxyeicosatrienoic acids, in the context of the cerebral vasculature and its contribution to the sexual dimorphic nature of stroke.

引用

收藏

页码：381 / 389

页数：9

相关论文

共 68 条

[1] Estrogen and Bcl-2: Gene induction and effect of transgene in experimental stroke [J].

Alkayed, NJ ;

Goto, S ;

Sugo, N ;

Joh, HD ;

Klaus, J ;

Crain, BJ ;

Bernard, O ;

Traystman, RJ ;

Hurn, PD .

JOURNAL OF NEUROSCIENCE, 2001, 21 (19) :7543-7550

[2] Neuroprotection and P4502C11 upregulation after experimental transient ischemic attack [J].

Alkayed, NJ ;

Goyagi, T ;

Joh, HD ;

Klaus, J ;

Harder, DR ;

Traystman, RJ ;

Hurn, PD .

STROKE, 2002, 33 (06) :1677-1684

[3] Gender-linked brain injury in experimental stroke [J].

Alkayed, NJ ;

Harukuni, I ;

Kimes, AS ;

London, ED ;

Traystman, RJ ;

Hurn, PD .

STROKE, 1998, 29 (01) :159-165

[4] BRAIN SYNTHESIS AND CEREBROVASCULAR ACTION OF EPOXYGENASE METABOLITES OF ARACHIDONIC-ACID [J].

AMRUTHESH, SC ;

FALCK, JR ;

ELLIS, EF .

JOURNAL OF NEUROCHEMISTRY, 1992, 58 (02) :503-510

[5] Sex Differences in Stroke Epidemiology A Systematic Review [J].

Appelros, Peter ;

Stegmayr, Birgitta ;

Terent, Andreas .

STROKE, 2009, 40 (04) :1082-1090

[6] Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-α in a rodent experimental stroke model [J].

Ardelt, AA ;

McCullough, LD ;

Korach, KS ;

Wang, MM ;

Munzenmaier, DH ;

Hurn, PD .

STROKE, 2005, 36 (02) :337-341

[7] RELATIONSHIP OF BRAIN VASCULATURE TO PRODUCTION OF NEUROLOGICAL DEFICIT AND MORPHOLOGICAL CHANGES FOLLOWING ACUTE UNILATERAL COMMON CAROTID-ARTERY LIGATION IN GERBILS [J].

BERRY, K ;

WISNIEWSKI, HM ;

SVARZBEIN, L ;

BAEZ, S .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1975, 25 (01) :75-92

[8] Inducible nitric oxide synthase and estradiol exhibit complementary neuroprotective roles after ischemic brain injury [J].

Brown, Candice M. ;

Dela Cruz, Christopher D. ;

Yang, Enhua ;

Wise, Phyllis M. .

EXPERIMENTAL NEUROLOGY, 2008, 210 (02) :782-787

[9] Epoxyeicosatrienoic acids and endothelium-dependent responses [J].

Campbell, William B. ;

Fleming, Ingrid .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2010, 459 (06) :881-895

[10] Investigation of estrogen status and increased stroke sensitivity on cerebral blood flow after a focal ischemic insult [J].

Carswell, HVO ;

Anderson, NH ;

Morton, JJ ;

McCulloch, J ;

Dominiczak, AF ;

Macrae, IM .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2000, 20 (06) :931-936

← 1 2 3 4 5 6 7 →