Emerging regulation and functions of autophagy

被引：1019

作者：

Boya, Patricia ^{[1
]}

Reggiori, Fulvio ^{[2
,3
]}

Codogno, Patrice ^{[4
]}

机构：

[1] CSIC, Ctr Invest Biol, Dept Cellular & Mol Biol, Madrid 28040, Spain

[2] Univ Med Ctr Utrecht, Dept Cell Biol, NL-3584 CX Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Inst Biomembranes, NL-3584 CX Utrecht, Netherlands

[4] Univ Paris 05, INSERM U845, Necker Growth & Signaling Res Ctr, F-75014 Paris, France

来源：

NATURE CELL BIOLOGY | 2013年 / 15卷 / 07期

关键词：

SELECTIVE AUTOPHAGY; UNCONVENTIONAL SECRETION; ENDOPLASMIC-RETICULUM; INDEPENDENTLY TARGET; AEROBIC GLYCOLYSIS; MEDIATED CLEAVAGE; ATG PROTEINS; TUMOR-GROWTH; CELL-DEATH; PHOSPHORYLATION;

D O I：

10.1038/ncb2788

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses - indicating the novel frontiers lying ahead.

引用

页码：713 / 720

页数：8

共 91 条

[1] Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum [J].

Axe, Elizabeth L. ;

Walker, Simon A. ;

Manifava, Maria ;

Chandra, Priya ;

Roderick, H. Llewelyn ;

Habermann, Anja ;

Griffiths, Gareth ;

Ktistakis, Nicholas T. .

JOURNAL OF CELL BIOLOGY, 2008, 182 (04) :685-701

[2] Network organization of the human autophagy system [J].

Behrends, Christian ;

Sowa, Mathew E. ;

Gygi, Steven P. ;

Harper, J. Wade .

NATURE, 2010, 466 (7302) :68-U84

[3] Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion [J].

Bruns, Caroline ;

McCaffery, J. Michael ;

Curwin, Amy J. ;

Duran, Juan M. ;

Malhotra, Vivek .

JOURNAL OF CELL BIOLOGY, 2011, 195 (06) :979-992

[4] Segregation and rapid turnover of EDEM1 by an autophagy-like mechanism modulates standard ERAD and folding activities [J].

Cali, Tito ;

Galli, Carmela ;

Olivari, Silvia ;

Molinari, Maurizio .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 371 (03) :405-410

[5] Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production [J].

Capparelli, Claudia ;

Guido, Carmela ;

Whitaker-Menezes, Diana ;

Bonuccelli, Gloria ;

Balliet, Renee ;

Pestell, Timothy G. ;

Goldberg, Allison F. ;

Pestell, Richard G. ;

Howell, Anthony ;

Sneddon, Sharon ;

Birbe, Ruth ;

Tsirigos, Aristotelis ;

Martinez-Outschoorn, Ubaldo ;

Sotgia, Federica ;

Lisanti, Michael P. .

CELL CYCLE, 2012, 11 (12) :2285-2302

[6] miR-375 Inhibits Autophagy and Reduces Viability of Hepatocellular Carcinoma Cells Under Hypoxic Conditions [J].

Chang, Ying ;

Yan, Wei ;

He, Xingxing ;

Zhang, Lemeng ;

Li, Chuanjiang ;

Huang, Hai ;

Nace, Gary ;

Geller, David A. ;

Lin, Jusheng ;

Tsung, Allan .

GASTROENTEROLOGY, 2012, 143 (01) :177-U357

[7] Regulation of the autophagy protein LC3 by phosphorylation [J].

Cherra, Salvatore J., III ;

Kulich, Scott M. ;

Uechi, Guy ;

Balasubramani, Manimalha ;

Mountzouris, John ;

Day, Billy W. ;

Chu, Charleen T. .

JOURNAL OF CELL BIOLOGY, 2010, 190 (04) :533-539

[8] Canonical and non-canonical autophagy: variations on a common theme of self-eating? [J].

Codogno, Patrice ;

Mehrpour, Maryam ;

Proikas-Cezanne, Tassula .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2012, 13 (01) :7-12

[9] Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation [J].

Deretic, Vojo ;

Jiang, Shanya ;

Dupont, Nicolas .

TRENDS IN CELL BIOLOGY, 2012, 22 (08) :397-406

[10] Autophagy, Immunity, and Microbial Adaptations [J].

Deretic, Vojo ;

Levine, Beth .

CELL HOST & MICROBE, 2009, 5 (06) :527-549

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