"Resuscitation time bias"-A unique challenge for observational cardiac arrest research

被引：188

作者：

Andersen, Lars W. ^{[1
,2
]}

Grossestreuer, Anne V. ^{[2
]}

Donnino, Michael W. ^{[2
,3
]}

机构：

[1] Aarhus Univ Hosp, Dept Clin Med, Res Ctr Emergency Med, Norrebrogade 44,Bldg 1B,1st Floor, DK-8000 Aarhus C, Denmark

[2] Beth Israel Deaconess Med Ctr, Dept Emergency Med, Ctr Resuscitat Sci, Boston, MA 02215 USA

[3] Beth Israel Deaconess Med Ctr, Dept Med, Div Pulm & Crit Care Med, Boston, MA 02215 USA

来源：

RESUSCITATION | 2018年 / 125卷

关键词：

Epidemiology; Bias; Immortal time bias; Resuscitation; MARGINAL STRUCTURAL MODELS; TRACHEAL INTUBATION; COX REGRESSION; SURVIVAL; ASSOCIATION; EPINEPHRINE; DURATION;

D O I：

10.1016/j.resuscitation.2018.02.006

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Observational studies are prone to a number of biases. One of these is immortal time bias. In this manuscript, we discuss immortal time bias as it pertains to post-cardiac arrest research and describes a related bias which we term "resuscitation time bias". This bias can occur when studying exposures during cardiac arrest. In this unique situation, an exposure is more likely to occur the longer the cardiac arrest continues. Since length of resuscitation is strongly associated with worse outcome, this will bias the results toward a harmful effect of the exposure. We discuss this bias and present methods to account for it.

引用

页码：79 / 82

页数：4

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