Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: Implications for vaccine development

被引:137
作者
Cao, HY
Kanki, P
Sankale, JL
DiengSarr, A
Mazzara, GP
Kalams, SA
Korber, B
Mboup, S
Walker, BD
机构
[1] MASSACHUSETTS GEN HOSP,CTR AIDS RES,BOSTON,MA 02114
[2] HARVARD UNIV,SCH MED,BOSTON,MA 02114
[3] HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115
[4] THERION BIOL,CAMBRIDGE,MA 02142
[5] LOS ALAMOS NATL LAB,LOS ALAMOS,NM 87545
[6] UNIV CHEIKH ANTA DIOP,LAB VIROL & BACTERIOL,DAKAR,SENEGAL
关键词
D O I
10.1128/JVI.71.11.8615-8623.1997
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Despite recent advances in antiviral therapy for human immunodeficiency virus (HIV) infection, successful global intervention will require an effective vaccine, Expanding evidence suggests that cytotoxic T-lymphocyte (CTL) responses will be an important component of such a vaccine, The varying geographic distribution of HIV type 1 (HIV-1) clades, with the relative absence of clade B HIV-1 outside the developed world, is considered a major obstacle to the development of a single efficacious vaccine, An understanding of cross-reactive CTL responses between different HIV-1 clades is crucial in the design of a vaccine which will be broadly immunogenic, In this study, we examined the ability of HIV-1 Gag-, reverse transcriptase-, and Env-specific CTL clones isolated from individuals infected in the United States to recognize non-B clade viral sequences and found that all were cross-reactive with the majority of non-B clade viral sequences tested. We next studied HIV-1-specific CTL responses in African individuals infected with clade A, C, or G virus and evaluated cross-recognition of clade B virus, Of 14 persons evaluated, all demonstrated cross-reactivity with the U.S. clade B viral constructs, We conclude that significant CTL cross-reactivity exists between clade B and non-B epitopes, suggesting that CTL cross-recognition among HIV-1 clades is more widespread than anticipated and that a vaccine based on a single clade may be broadly applicable.
引用
收藏
页码:8615 / 8623
页数:9
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