Regulatory mechanism and therapeutic potentials of naringin against inflammatory disorders

被引:25
作者
Peng, Yuan [1 ]
Qu, Ruyi [1 ]
Xu, Shuqin [1 ]
Bi, Hongsheng [2 ]
Guo, Dadong [3 ]
机构
[1] Shandong Univ Tradit Chinese Med, Jinan 250002, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Affiliated Eye Hosp, Jinan 250002, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Shandong Acad Eye Dis Prevent & Therapy, Med Coll Optometry & Ophthalmol, Shandong Prov Key Lab Integrated Tradit Chinese &, Jinan 250002, Peoples R China
基金
中国国家自然科学基金;
关键词
Naringin; Inflammatory disease; Anti-Inflammatory; Antioxidant; NF-KAPPA-B; JUICE FELODIPINE INTERACTION; INDUCED INTESTINAL INJURY; GRAPEFRUIT JUICE; PPAR-GAMMA; TOXICOLOGICAL EVALUATION; MACROPHAGE POLARIZATION; ACTIVATION; INHIBITION; PROTECTS;
D O I
10.1016/j.heliyon.2024.e24619
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
Naringin is a natural flavonoid with therapeutic properties found in citrus fruits and an active natural product from herbal plants. Naringin has become a focus of attention in recent years because of its ability to actively participate in the body's immune response and maintain the integrity of the immune barrier. This review aims to elucidate the mechanism of action and therapeutic efficacy of naringin in various inflammatory diseases and to provide a valuable reference for further research in this field. The review provided the chemical structure, bioavailability, pharmacological properties, and pharmacokinetics of naringin and found that naringin has good therapeutic potential for inflammatory diseases, exerting anti-inflammatory, anti-apoptotic, anti-oxidative stress, anti-ulcerative and detoxifying effects in the disease. Moreover, we found that the great advantage of naringin treatment is that it is safe and can even alleviate the toxic side effects associated with some of the other drugs, which may become a highlight of naringin research. Naringin, an active natural product, plays a significant role in systemic diseases' anti-inflammatory and antioxidant regulation through various signaling pathways and molecular mechanisms.
引用
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页数:17
相关论文
共 196 条
[1]
Enhanced Antioxidant Effects of Naringenin Nanoparticles Synthesized using the High-Energy Ball Milling Method [J].
Ahmad, Anas ;
Prakash, Ravi ;
Khan, Mohd Shahnawaz ;
Altwaijry, Nojood ;
Asghar, Muhammad Nadeem ;
Raza, Syed Shadab ;
Khan, Rehan .
ACS OMEGA, 2022, :34476-34484
[2]
Naringin Attenuates the Development of Carrageenan-Induced Acute Lung Inflammation Through Inhibition of NF-κb, STAT3 and Pro-Inflammatory Mediators and Enhancement of IκBα and Anti-Inflammatory Cytokines [J].
Ahmad, Sheikh Fayaz ;
Attia, Sabry M. ;
Bakheet, Saleh A. ;
Zoheir, Khairy M. A. ;
Ansari, Mushtaq Ahmad ;
Korashy, Hesham M. ;
Abdel-Hamied, Hala E. ;
Ashour, Abdelkader E. ;
Abd-Allah, Adel R. A. .
INFLAMMATION, 2015, 38 (02) :846-857
[3]
Therapeutic potential of naringin in neurological disorders [J].
Ahmed, Salman ;
Khan, Haroon ;
Aschner, Michael ;
Hasan, Muhammad Mohtasheemul ;
Hassan, Sherif T. S. .
FOOD AND CHEMICAL TOXICOLOGY, 2019, 132
[4]
Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation [J].
Aihaiti, Yirixiati ;
Song Cai, Yong ;
Tuerhong, Xiadiye ;
Ni Yang, Yan ;
Ma, Yao ;
Shi Zheng, Hai ;
Xu, Ke ;
Xu, Peng .
FRONTIERS IN PHARMACOLOGY, 2021, 12
[5]
Naringin prevents cyclophosphamide-induced hepatotoxicity in rats by attenuating oxidative stress, fibrosis, and inflammation [J].
Akamo, Adio J. ;
Rotimi, Solomon O. ;
Akinloye, Dorcas, I ;
Ugbaja, Regina N. ;
Adeleye, Oluwagbemiga O. ;
Dosumu, Oluwatosin A. ;
Eteng, Ofem E. ;
Amah, Gogonte ;
Obijeku, Augustine ;
Cole, Oluwatosin E. .
FOOD AND CHEMICAL TOXICOLOGY, 2021, 153
[6]
Twelve-Week Mediterranean Diet Intervention Increases Citrus Bioflavonoid Levels and Reduces Inflammation in People with Type 2 Diabetes Mellitus [J].
Al-Aubaidy, Hayder A. ;
Dayan, Aanchal ;
Deseo, Myrna A. ;
Itsiopoulos, Catherine ;
Jamil, Dina ;
Hadi, Najah R. ;
Thomas, Colleen J. .
NUTRIENTS, 2021, 13 (04)
[7]
Meticulous parade on naringin respecting its pharmacological activities and novel formulations [J].
Alam, Mahboob ;
Ahsan, Farogh ;
Mahmood, Tarique ;
Shamim, Arshiya ;
Parveen, Saba ;
Shariq, Mohammad ;
Ansari, Vaseem Ahmad .
AVICENNA JOURNAL OF PHYTOMEDICINE, 2022, 12 (05) :457-474
[8]
Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies [J].
Ali, Amira Mohammed ;
Kunugi, Hiroshi .
MOLECULES, 2021, 26 (05)
[9]
Naringin-loaded Arabic gum/pectin hydrogel as a potential wound healing material [J].
Alsakhawy, Marwa A. ;
Abdelmonsif, Doaa A. ;
Haroun, Medhat ;
Sabra, Sally A. .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 222 :701-714
[10]
Amini N, 2022, AVICENNA J PHYTOMEDI, V12, P357, DOI [10.22038/AJP.2022.19620, 10.22038/ajp.2022.19620]