神经生长因子对脑缺血再灌注后生长相关蛋白和突触素表达的影响

被引：7

作者：

郭宗君

丰岩清

郭云良

石秉霞

机构：

[1] 青岛大学医学院脑血管病研究所,青岛大学医学院脑血管病研究所,青岛大学医学院脑血管病研究所,青岛大学医学院脑血管病研究所

来源：

中华物理医学与康复杂志 | 2000年 / 04期

关键词：

神经生长因子; 脑缺血; 生长相关蛋白; 突触素; 大鼠;

D O I：

暂无

中图分类号：

R364 [病理过程];

学科分类号：

100104 ;

摘要：

目的　研究外源性神经生长因子 (NGF)对大鼠脑缺血再灌注后生长相关蛋白 43 (GAP 43 )和突触素 p3 8表达的影响。方法　成年健康雌性Wistar大鼠 5 4只 ,随机分为NGF治疗组、对照组和假手术组。采用线栓法建立大脑中动脉缺血再灌注动物模型 ,应用免疫组织化学方法观察NGF对脑缺血再灌注后GAP 43和p3 8表达的影响。结果　脑室注射外缘性NGF后 ,GAP 43和p3 8表达较对照组有所增高 ,但差异无显著性 ( P >0 .0 5 )。结论　提示GAP 43和 p3 8是中枢神经系统损伤和再生的分子标志物 ,外源性NGF对GAP 43和 p3 8的调节有待于进一步研究。

引用

页码：8 / 10+65

页数：4

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