上海地区幽门螺杆菌菌株iceA、babA2基因型与临床的关系

被引：13

作者：

韩跃华

刘文忠

朱红音

萧树东

机构：

[1] 上海第二医科大学附属仁济医院上海市消化疾病研究所,上海第二医科大学附属仁济医院上海市消化疾病研究所,上海第二医科大学附属仁济医院上海市消化疾病研究所,上海第二医科大学附属仁济医院上海市消化疾病研究所,,,

来源：

中华消化杂志 | 2004年 / 06期

关键词：

幽门螺杆菌; 临床结局; iceA; babA2; cagA; vacA;

D O I：

暂无

中图分类号：

R573 [胃疾病];

学科分类号：

1002 ; 100201 ;

摘要：

目的　检测上海地区幽门螺杆菌 (Hp)感染患者中Hp菌株iceA、babA2的分布特征 ,探讨与Hp临床感染结局相关的菌株基因型。方法　 1 4 1株Hp菌株分离自 4 3例慢性胃炎 (CG)、4 7例十二指肠球部溃疡 (DU)、30例胃溃疡 (GU)和 2 1例非贲门部胃癌患者的胃镜活检标本。采用PCR方法检测Hp菌株的iceA、babA2、cagA和vacA基因型。结果　 1 4 1株Hp菌株中 ,iceA1、iceA2和babA2的总检出率分别为 74 .5 % (1 0 5 /1 4 1 )、1 5 .6 % (2 2 /1 4 1 )和 6 3.8% (90 /1 4 1 ) ,其中 2例 (1 .4 % )为iceA1、iceA2均阳性 ,1 6例 (1 1 .3% )为iceA1、iceA2均阴性。DU组的babA2检出率显著高于GU组 (74 .5 %比5 0 .0 % ,P =0 .0 2 8) ,DU组的cagA+ /babA2 + 检出率亦显著高于GU组 (70 .2 %比 4 6 .7% ,P =0 .0 39)。其余疾病组之间的babA2检出率差异无显著性。未发现不同临床疾病与iceA基因型的相关性。结论　上海地区Hp感染者的菌株基因型主要是iceA1 + /babA2 + ,babA2在DU和GU的发病机制中起不同作用。未发现iceA亚型与Hp临床感染结局有相关性

引用

页码：5 / 8

页数：4

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