“合成生物学”研究前沿与发展趋势

被引:22
作者
王璞玥 [1 ]
唐鸿志 [2 ]
吴震州 [3 ]
孟庆峰 [1 ]
杨正宗 [1 ]
杜生明 [1 ]
冯雪莲 [1 ]
机构
[1] 国家自然科学基金委员会生命科学部
[2] 上海交通大学
[3] 南开大学
关键词
合成生物学; 基础研究; 研究现状; 前沿方向; 重要科学问题;
D O I
10.16262/j.cnki.1000-8217.2018.05.015
中图分类号
Q81 [生物工程学(生物技术)];
学科分类号
0836 ; 090102 ;
摘要
合成生物学是关于设计和重新合成生命的一门新兴交叉融合性学科,是利用基因组测序技术、计算机模拟技术、生物工程技术和化学合成技术等,在工程学思想的指导下,通过设计生命、合成再造、重塑生命,开创全新科学研究模式,在生命科学、化学、材料学、医药与健康等多领域形成颠覆性技术。随着合成生物技术和基因编辑技术的迅速突破,合成生命有可能成为我国实现颠覆性原始创新的领域之一,为全社会带来全新的机遇与挑战。本综述围绕第193期"双清论坛"展开,聚焦于基础研究与应用基础研究,总结了"合成生物学"的研究进展、发展趋势和前沿科学问题;结合我国在该领域的研究现状和优势,分析和凝练了我国亟待关注的重要基础科学问题,探讨了前沿研究方向和应重点关注的科学问题。
引用
收藏
页码:545 / 551
页数:7
相关论文
共 14 条
[1]  
酿酒酵母染色体设计与合成研究进展[J]. 徐赫鸣,谢泽雄,刘夺,吴毅,李炳志,元英进.遗传. 2017(10)
[2]   Multiple Approaches to the Investigation of Cell Assembly in Memory Research-Present and Future [J].
Sakurai, Yoshio ;
Osako, Yuma ;
Tanisumi, Yuta ;
Ishihara, Eriko ;
Hirokawa, Junya ;
Manabe, Hiroyuki .
FRONTIERS IN SYSTEMS NEUROSCIENCE, 2018, 12
[3]  
Metabolic regulation in solventogenic clostridia: regulators, mechanisms and engineering[J] . Yunpeng Yang,Xiaoqun Nie,Yuqian Jiang,Chen Yang,Yang Gu,Weihong Jiang.Biotechnology Advances . 2018 (4)
[4]   Construction of Halomonas bluephagenesis capable of high cell density growth for efficient PHA production [J].
Ren, Yilin ;
Ling, Chen ;
Hajnal, Ivan ;
Wu, Qiong ;
Chen, Guo-Qiang .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2018, 102 (10) :4499-4510
[5]   Intelligent Microbial Heat-Regulating Engine (IMHeRE) for Improved Thermo-Robustness and Efficiency of Bioconversion [J].
Jia, Haiyang ;
Sun, Xiangying ;
Sun, Huan ;
Li, Chenyi ;
Wang, Yunqian ;
Feng, Xudong ;
Li, Chun .
ACS SYNTHETIC BIOLOGY, 2016, 5 (04) :312-320
[6]  
Production of natural products through metabolic engineering of Saccharomyces cerevisiae[J] . Anastasia Krivoruchko,Jens Nielsen.Current Opinion in Biotechnology . 2015
[7]  
De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae[J] . Mingji Li,Kanchana R. Kildegaard,Yun Chen,Angelica Rodriguez,Irina Borodina,Jens Nielsen.Metabolic Engineering . 2015
[8]   Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery [J].
Wroblewska, Liliana ;
Kitada, Tasuku ;
Endo, Kei ;
Siciliano, Velia ;
Stillo, Breanna ;
Saito, Hirohide ;
Weiss, Ron .
NATURE BIOTECHNOLOGY, 2015, 33 (08) :839-+
[9]   Total Synthesis of a Functional Designer Eukaryotic Chromosome [J].
Annaluru, Narayana ;
Muller, Heloise ;
Mitchell, Leslie A. ;
Ramalingam, Sivaprakash ;
Stracquadanio, Giovanni ;
Richardson, Sarah M. ;
Dymond, Jessica S. ;
Kuang, Zheng ;
Scheifele, Lisa Z. ;
Cooper, Eric M. ;
Cai, Yizhi ;
Zeller, Karen ;
Agmon, Neta ;
Han, Jeffrey S. ;
Hadjithomas, Michalis ;
Tullman, Jennifer ;
Caravelli, Katrina ;
Cirelli, Kimberly ;
Guo, Zheyuan ;
London, Viktoriya ;
Yeluru, Apurva ;
Murugan, Sindurathy ;
Kandavelou, Karthikeyan ;
Agier, Nicolas ;
Fischer, Gilles ;
Yang, Kun ;
Martin, J. Andrew ;
Bilgel, Murat ;
Bohutski, Pavlo ;
Boulier, Kristin M. ;
Capaldo, Brian J. ;
Chang, Joy ;
Charoen, Kristie ;
Choi, Woo Jin ;
Deng, Peter ;
DiCarlo, James E. ;
Doong, Judy ;
Dunn, Jessilyn ;
Feinberg, Jason I. ;
Fernandez, Christopher ;
Floria, Charlotte E. ;
Gladowski, David ;
Hadidi, Pasha ;
Ishizuka, Isabel ;
Jabbari, Javaneh ;
Lau, Calvin Y. L. ;
Lee, Pablo A. ;
Li, Sean ;
Lin, Denise ;
Linder, Matthias E. .
SCIENCE, 2014, 344 (6179) :55-58
[10]   Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems [J].
DiCarlo, James E. ;
Norville, Julie E. ;
Mali, Prashant ;
Rios, Xavier ;
Aach, John ;
Church, George M. .
NUCLEIC ACIDS RESEARCH, 2013, 41 (07) :4336-4343